INT23440

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Context Info
Confidence 0.45
First Reported 1980
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 1.77
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sult1b1) cytoplasm (Sult1b1)
Anatomy Link Frequency
median eminence 3
neurons 1
brain 1
ganglion 1
Sult1b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 5 100.00 Very High Very High Very High
tetrodotoxin 5 99.84 Very High Very High Very High
Enkephalin 6 99.52 Very High Very High Very High
noradrenaline 13 99.30 Very High Very High Very High
gABA 30 98.72 Very High Very High Very High
agonist 3 98.64 Very High Very High Very High
Dopamine 28 96.86 Very High Very High Very High
Hippocampus 3 96.36 Very High Very High Very High
Clonidine 4 95.12 Very High Very High Very High
adenocard 3 89.32 High High
Disease Link Frequency Relevance Heat
Convulsion 9 100.00 Very High Very High Very High
Ganglion Cysts 4 96.12 Very High Very High Very High
Stress 5 92.60 High High
Pressure Volume 2 Under Development 4 75.00 Quite High
Heart Rate Under Development 3 75.00 Quite High
Galactorrhea 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Metiamide (800 micrograms intracerebroventricularly to rats) enhanced the DOPA accumulation in noradrenaline-predominant brain areas following DOPA decarboxylase inhibition and it accelerated the alpha-methyltyrosine-induced disappearance of noradrenaline in the brain, both normally and after clonidine (0.1 mg/kg i.p.).
Negative_regulation (inhibition) of DOPA in brain associated with noradrenaline and clonidine
1) Confidence 0.45 Published 1980 Journal J. Neural Transm. Section Abstract Doc Link 6770044 Disease Relevance 0 Pain Relevance 0.43
Furthermore, the effect of L-DOPA on the convulsions was inhibited by the combination of 5-HTP. alpha-Methyl-p-tyrosine (20-80 mg/kg, i.p.) or DL-p-chlorophenylalanine (20-80 mg/kg, i.p.), an inhibitor of NE and DA or 5-HT biosynthesis, had a slight effect on the convulsions.
Negative_regulation (inhibited) of L-DOPA associated with dopamine and convulsion
2) Confidence 0.37 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2622091 Disease Relevance 0.66 Pain Relevance 0.61
Dopamine biosynthesis in TIDA neurons was estimated by the rate of in vitro dihydroxyphenylalanine (DOPA) accumulation in the median eminence of rat hypothalamic slices after incubation with a DOPA decarboxylase inhibitor.
Negative_regulation (inhibitor) of DOPA in median eminence associated with dopamine
3) Confidence 0.22 Published 1986 Journal Brain Res. Section Abstract Doc Link 2424558 Disease Relevance 0 Pain Relevance 0.25
In vitro dopamine synthesis in TIDA neurons was estimated by measuring 3,4-dihydroxyphenylalanine (DOPA) accumulated in the median eminence after incubation of hypothalamic slices with a DOPA decarboxylase inhibitor.
Negative_regulation (inhibitor) of DOPA in neurons associated with dopamine
4) Confidence 0.13 Published 1986 Journal Endocrinology Section Abstract Doc Link 3019639 Disease Relevance 0.07 Pain Relevance 0.41
The rate of dopamine biosynthesis was estimated by in vitro dihydroxyphenylalanine (DOPA) synthesis in the median eminence following incubation of rat hypothalamic slices with a DOPA decarboxylase inhibitor.
Negative_regulation (inhibitor) of DOPA in median eminence associated with dopamine
5) Confidence 0.12 Published 1985 Journal Brain Res. Section Abstract Doc Link 2415215 Disease Relevance 0 Pain Relevance 0.13
Dopamine synthesis in vitro in TIDA neurons was estimated by 3,4-dihydroxyphenylalanine (DOPA) accumulation in the median eminence after incubation of slices with a DOPA decarboxylase inhibitor.
Negative_regulation (inhibitor) of DOPA in median eminence associated with dopamine
6) Confidence 0.05 Published 1988 Journal Endocrinology Section Abstract Doc Link 3135174 Disease Relevance 0 Pain Relevance 0.44
Veratridine-stimulated DOPA accumulation is blocked by tetrodotoxin, but not by cholinergic or adrenergic antagonists or by decentralization of the ganglion.
Negative_regulation (blocked) of DOPA in ganglion associated with ganglion cysts, tetrodotoxin and antagonist
7) Confidence 0.05 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6141219 Disease Relevance 0.36 Pain Relevance 0.15
DOPA ME, a competitive DOPA antagonist, did not displace specific [3H]GABA binding.
Negative_regulation (antagonist) of DOPA associated with gaba and antagonist
8) Confidence 0.04 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10081935 Disease Relevance 0.15 Pain Relevance 0.47
DOPA ME, a competitive DOPA antagonist, did not displace specific [3H]GABA binding.
Negative_regulation (antagonist) of DOPA associated with gaba and antagonist
9) Confidence 0.04 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10081935 Disease Relevance 0.15 Pain Relevance 0.48
GABA seems to inhibit tonically via GABA(A) receptors depressor responses to DOPA and to elicit pressor responses partially by inhibition of tonic function of endogenous DOPA to activate depressor sites in the NTS.
Negative_regulation (inhibition) of DOPA associated with gaba
10) Confidence 0.04 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10081935 Disease Relevance 0.15 Pain Relevance 0.46
After administering a DOPA decarboxylase inhibitor, the in vivo tyrosine hydroxylase activity and the noradrenaline content were evaluated.
Negative_regulation (inhibitor) of DOPA associated with noradrenaline
11) Confidence 0.03 Published 2002 Journal Pharmacology Section Abstract Doc Link 11901301 Disease Relevance 0 Pain Relevance 0.34
After administering a 3,4-dihydroxyphenylalanine (DOPA) decarboxylase inhibitor, tyrosine hydroxylase activity, measured as the accumulation of DOPA, and noradrenaline (NA) content were determined by using high-performance liquid chromatography.
Negative_regulation (inhibitor) of DOPA associated with noradrenaline
12) Confidence 0.02 Published 2003 Journal Stress Section Abstract Doc Link 14660060 Disease Relevance 0.22 Pain Relevance 0.17

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