INT23441

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Context Info
Confidence 0.14
First Reported 1985
Last Reported 1985
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.30
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sult1b1) cytoplasm (Sult1b1)
Anatomy Link Frequency
median eminence 4
Sult1b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 4 97.28 Very High Very High Very High
Dopamine 12 94.80 High High
antagonist 1 94.52 High High
addiction 1 89.40 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 79.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Ca2+ channel blockers verapamil (100 microM) and Co2+ (4 mM) were effective in reducing the depolarization-induced DOPA synthesis.
Negative_regulation (reducing) of Gene_expression (synthesis) of DOPA
1) Confidence 0.14 Published 1985 Journal Brain Res. Section Abstract Doc Link 2415215 Disease Relevance 0 Pain Relevance 0.23
Removal of Ca2+ and addition of EGTA (1 mM) into the medium did not influence basal DOPA synthesis in the median eminence but blocked the K+- and veratridine-induced DOPA synthesis.
Negative_regulation (blocked) of Gene_expression (synthesis) of DOPA in median eminence
2) Confidence 0.10 Published 1985 Journal Brain Res. Section Abstract Doc Link 2415215 Disease Relevance 0 Pain Relevance 0.22
On the other hand, tetrodotoxin (2 microM), a Na+ channel blocker, did not change the basal and K+-induced DOPA synthesis in the median eminence whereas it completely inhibited the veratridine-induced DOPA synthesis.
Negative_regulation (inhibited) of Gene_expression (synthesis) of DOPA in median eminence associated with tetrodotoxin
3) Confidence 0.10 Published 1985 Journal Brain Res. Section Abstract Doc Link 2415215 Disease Relevance 0 Pain Relevance 0.24
The stimulation of DOPA synthesis in low-Na+ medium was inhibited by methoxyverapamil, an inhibitor of Ca2+ uptake, and was partially blocked by tetrodotoxin, but it was not affected by the cholinergic antagonists hexamethonium and atropine.
Negative_regulation (inhibited) of Gene_expression (synthesis) of DOPA associated with tetrodotoxin and antagonist
4) Confidence 0.02 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2857766 Disease Relevance 0.30 Pain Relevance 0.19

General Comments

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