INT234410

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.66
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ISG20) nucleoplasm (ISG20) RNA binding (ISG20)
nucleus (ISG20) intracellular (ISG20)
Anatomy Link Frequency
IL2R 1
regulatory T cells 1
T-cells 1
ISG20 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 30 95.12 Very High Very High Very High
cytokine 47 92.56 High High
vincristine 2 86.72 High High
agonist 13 68.48 Quite High
chemokine 2 58.56 Quite High
corticosteroid 37 43.68 Quite Low
tolerance 4 27.52 Quite Low
fibrosis 10 5.00 Very Low Very Low Very Low
Paracetamol 9 5.00 Very Low Very Low Very Low
pruritus 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 23 98.20 Very High Very High Very High
INFLAMMATION 30 95.12 Very High Very High Very High
Lymphatic System Cancer 103 94.16 High High
Apoptosis 65 91.68 High High
Autoimmune Disease 6 91.68 High High
Disease 57 88.80 High High
Toxicity 7 81.80 Quite High
Chronic Disease 2 78.96 Quite High
Death 23 74.76 Quite High
Diphtheria 14 67.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Initally, it was thought that the presence of CD25 was required for entry of the drug into the malignant T-cells, however, recent evidence has shown durable responses in patients with CD25?
CD25 Binding (presence) of in T-cells associated with malignant neoplastic disease
1) Confidence 0.22 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.87 Pain Relevance 0.04
We know now that the IL2R is a complex comprised by three parts: the alpha chain (CD25) which is required for high affinity binding, the beta chain (CD122) which participates in IL2 and IL15 signal transduction, and the common gamma chain (CD132) which participates in downstream signal transduction of IL2 and other cytokines.11–14
CD25 Binding (binding) of in IL2R associated with cytokine
2) Confidence 0.22 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.31 Pain Relevance 0.05
activation enhanced the generation of CD4+ CD25+ regulatory T cells (Tregs).
CD25 Binding (generation) of in regulatory T cells
3) Confidence 0.17 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.38 Pain Relevance 0.06
in fostering commitment of naïve CD4+CD25?
CD25 Binding (commitment) of
4) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.10 Pain Relevance 0.08
The IL-2 receptor is composed of three noncovalently bound chains: CD25 (a 55 kilodalton kD alpha chain); a 75?
CD25 Binding (bound) of
5) Confidence 0.06 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0 Pain Relevance 0.03

General Comments

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