INT234422

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 15.93
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (PML) nucleoplasm (PML) endoplasmic reticulum (PML)
intracellular (PML) protein complex assembly (PML) DNA binding (PML)
Anatomy Link Frequency
U-2 OS 3
PML (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 75 96.80 Very High Very High Very High
Multiple sclerosis 259 96.76 Very High Very High Very High
Central nervous system 37 96.56 Very High Very High Very High
corticosteroid 33 93.32 High High
Demyelination 18 88.24 High High
cerebral cortex 4 85.20 High High
headache 16 81.84 Quite High
withdrawal 9 81.44 Quite High
anesthesia 6 80.64 Quite High
imagery 69 72.36 Quite High
Disease Link Frequency Relevance Heat
Disease 430 100.00 Very High Very High Very High
Progressive Multifocal Leukoencephalopathy 227 100.00 Very High Very High Very High
Epstein-barr Virus 16 100.00 Very High Very High Very High
Mycobacterial Infection 5 99.12 Very High Very High Very High
Opportunistic Infections 15 99.04 Very High Very High Very High
Demyelinating Disease 297 98.64 Very High Very High Very High
Lymphatic System Cancer 86 98.48 Very High Very High Very High
Leukemia 173 98.32 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 1 97.16 Very High Very High Very High
Acute Promyelocytic Leukemia 3 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
the generation of the PML/RAR?
Gene_expression (generation) of PML
1) Confidence 0.75 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.82 Pain Relevance 0
the generation of the PML/RAR?
Gene_expression (generation) of PML
2) Confidence 0.65 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.82 Pain Relevance 0
performed by Jansen et al. demonstrated that the abnormal PML-RAR?
Gene_expression (abnormal) of PML
3) Confidence 0.65 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 2.06 Pain Relevance 0
The first patient to develop PML in the SENTINEL trial was a 46-year-old female who had received 37 doses of natalizumab beginning in April 2002 through January 2005 as add on therapy to interferon ?
Gene_expression (develop) of PML associated with progressive multifocal leukoencephalopathy
4) Confidence 0.51 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724189 Disease Relevance 1.72 Pain Relevance 0.23
Progressive multifocal leukoencephalopathy (PML)
Gene_expression (Progressive) of PML associated with progressive multifocal leukoencephalopathy
5) Confidence 0.51 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724189 Disease Relevance 1.20 Pain Relevance 0.20
Progressive multifocal leukoencephalopathy (PML)
Gene_expression (Progressive) of PML associated with progressive multifocal leukoencephalopathy
6) Confidence 0.31 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789688 Disease Relevance 1.29 Pain Relevance 0.37
However PML is an aggressive disease and detection in the asymptomatic stage has rarely if ever been reported presumably because it becomes clinically manifest rapidly, often leading to death within a few months.37
Gene_expression (detection) of PML associated with progressive multifocal leukoencephalopathy, disease and death
7) Confidence 0.31 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789688 Disease Relevance 1.06 Pain Relevance 0.07
However PML is an aggressive disease and detection in the asymptomatic stage has rarely if ever been reported presumably because it becomes clinically manifest rapidly, often leading to death within a few months.37
Gene_expression (aggressive) of PML associated with progressive multifocal leukoencephalopathy, disease and death
8) Confidence 0.31 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789688 Disease Relevance 1.01 Pain Relevance 0.07
After extensive investigations the treating neurologist suspected PML and a CSF analysis for JC virus PCR was positive.
Gene_expression (positive) of PML associated with progressive multifocal leukoencephalopathy
9) Confidence 0.28 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789688 Disease Relevance 1.68 Pain Relevance 0.09
We used U-2 OS cells and indirect immunofluorescent detection of the PML protein (Fig. 5A) to monitor the effects of ectopically-expressed CHPKs on PML-NBs.
Gene_expression (detection) of PML in U-2 OS
10) Confidence 0.23 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0.23 Pain Relevance 0
We used U-2 OS cells and indirect immunofluorescent detection of the PML protein (Fig. 5A) to monitor the effects of ectopically-expressed CHPKs on PML-NBs.
Gene_expression (expressed) of PML in U-2 OS
11) Confidence 0.20 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0.22 Pain Relevance 0
Proteins that efficiently disrupt PML-NBs (HCMV IE1 and EBV Zta) are expressed within infected cells in vitro prior to the time when the CHPKs are expressed [101], [102], so the ability of the HHV-4 and HHV-5 CHPKs to decrease the numbers of PML-NBs when ectopically expressed may have limited relevance during viral infection.
Gene_expression (expressed) of PML associated with viral infection and epstein-barr virus
12) Confidence 0.18 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0.27 Pain Relevance 0
Based on accumulating data, the FDA has now issued warnings that the risk of PML increases with number of infusions.65

Mitoxantrone

Gene_expression (risk) of PML associated with progressive multifocal leukoencephalopathy
13) Confidence 0.18 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998807 Disease Relevance 1.48 Pain Relevance 0.09
For PML-NB disruption assays, U-2 OS cells grown on coverslips were transfected with an expression plasmid for the indicated CHPK or pCGN-IE1 [117].
Gene_expression (expression) of PML in U-2 OS
14) Confidence 0.18 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0.06 Pain Relevance 0

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