INT234430

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.79
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP8) peptidase activity (CASP8) mitochondrion (CASP8)
nucleolus (CASP8) cytoskeleton (CASP8) nucleus (CASP8)
CASP8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 11 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 281 98.64 Very High Very High Very High
Infection 26 93.60 High High
Chronic Lymphoid Leukemia 14 92.04 High High
Death 31 71.76 Quite High
Leukemia 54 71.20 Quite High
Disease 11 65.16 Quite High
Diffuse Large B-cell Lymphoma 11 63.44 Quite High
B-cell Lymphoma 2 63.16 Quite High
Lymphatic System Cancer 25 55.96 Quite High
Mantle-cell Lymphoma 1 47.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
affected the levels of an endogenous caspase-8 inhibitor, c-FLIP (caspase-8
Negative_regulation (inhibitor) of Gene_expression (levels) of caspase-8
1) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.52 Pain Relevance 0
These results indicate that mitochondrial-mediated apoptosis in HepG2 cells, triggered by DLS, is predominantly associated with down-regulation of the Bcl-2/Bax expression ratio.Fig. 3Western blot analysis of the expression levels of caspase3, caspase9, Bcl-2, Bax, caspase8 and DR5 with the treatment of DLS for 24 h (All the experiments were repeated four times.)Fig. 4Bcl-2, Bax, DR5 protein expression in HepG2 cells (×200). a, c, e Immunocytochemistry of Bcl-2, Bax and DR5 staining in HepG2 cells for 24 h of treatment without DLS. b, d, f Immunocytochemistry of Bcl-2, Bax and DR5 staining in HepG2 cells for 24 h of treatment with 25 ?
Negative_regulation (down) of Gene_expression (expression) of caspase8 associated with apoptosis
2) Confidence 0.05 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 0.64 Pain Relevance 0
These results indicate that mitochondrial-mediated apoptosis in HepG2 cells, triggered by DLS, is predominantly associated with down-regulation of the Bcl-2/Bax expression ratio.Fig. 3Western blot analysis of the expression levels of caspase3, caspase9, Bcl-2, Bax, caspase8 and DR5 with the treatment of DLS for 24 h (All the experiments were repeated four times.)Fig. 4Bcl-2, Bax, DR5 protein expression in HepG2 cells (×200). a, c, e Immunocytochemistry of Bcl-2, Bax and DR5 staining in HepG2 cells for 24 h of treatment without DLS. b, d, f Immunocytochemistry of Bcl-2, Bax and DR5 staining in HepG2 cells for 24 h of treatment with 25 ?
Negative_regulation (regulation) of Gene_expression (expression) of caspase8 associated with apoptosis
3) Confidence 0.05 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 0.64 Pain Relevance 0
Upregulation of TNFAIP3, TNFAIP8, TNFRSF12A, FAIM3, and CFLAR are important to inhibit caspase-8 activation, and may be direct targets of Shigella T3SS effector proteins or result from NF-?
Negative_regulation (inhibit) of Gene_expression (activation) of caspase-8
4) Confidence 0.04 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.99 Pain Relevance 0

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