INT234456

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.05
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR1H4) signal transduction (NR1H4) nucleus (NR1H4)
NR1H4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 99.28 Very High Very High Very High
agonist 21 87.20 High High
Inflammation 20 84.56 Quite High
cytokine 12 55.52 Quite High
metalloproteinase 28 50.00 Quite Low
Arthritis 6 23.24 Low Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
Osteoarthritis 10 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 24 99.04 Very High Very High Very High
Colon Cancer 19 95.56 Very High Very High Very High
Chondrosarcoma 12 86.44 High High
Colitis 1 83.84 Quite High
Cancer 36 71.20 Quite High
Apoptosis 11 43.00 Quite Low
Rheumatoid Arthritis 27 35.12 Quite Low
Arthritis 10 23.24 Low Low
Arthropathy 4 22.04 Low Low
Carcinoma 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
binding to the DR-1/AP-1 site in suppressing MMP-1 and MMP-13 production and addressed possible mechanisms of inhibition, including competitive binding between RXR:PPAR?
Spec (possible) Negative_regulation (mechanisms) of Gene_expression (competitive) of RXR
1) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.09 Pain Relevance 0.03
, ligands block MMP-1 and MMP-13 gene expression, RXR:PPAR?
Negative_regulation (block) of Gene_expression (expression) of RXR
2) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.15 Pain Relevance 0.04
requires a high-level expression of RXR?
Negative_regulation (level) of Gene_expression (expression) of RXR
3) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.81 Pain Relevance 0.25

General Comments

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