INT234461

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.74
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HDAC9) transcription factor binding (HDAC9) cytoplasm (HDAC9)
HDAC9 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 45 86.00 High High
Inflammation 64 60.16 Quite High
Inflammatory mediators 6 52.40 Quite High
cINOD 5 49.76 Quite Low
Nicotine 1 28.52 Quite Low
rheumatoid arthritis 74 14.20 Low Low
Osteoarthritis 36 5.00 Very Low Very Low Very Low
cytokine 13 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloproliferative Disorder 45 100.00 Very High Very High Very High
Cancer 124 99.16 Very High Very High Very High
Chronic Myeloid Leukemia 7 99.12 Very High Very High Very High
Lymphatic System Cancer 22 98.32 Very High Very High Very High
Myeloid Leukemia 30 94.72 High High
Apoptosis 41 92.76 High High
Philadelphia Chromosome 1 80.24 Quite High
Leukemia 17 79.72 Quite High
Prostate Cancer 1 77.12 Quite High
Disease 58 70.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, it is also reported that the histone deacetylase (HDAC) inhibitors have a
Negative_regulation (inhibitors) of Gene_expression (histone) of HDAC
1) Confidence 0.24 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.74 Pain Relevance 0.11
Measurement of HDAC activity
Negative_regulation (Measurement) of Gene_expression (activity) of HDAC
2) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0 Pain Relevance 0
Array data showed that the expression of a number of histone deacetylase (HDAC) genes (HDAC3, 7A, 11) was suppressed by PAR2 activation, as were the related sirtuins 2, 3, 5 and 6 (Table 6).
Negative_regulation (suppressed) of Gene_expression (expression) of HDAC
3) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.05 Pain Relevance 0.13
Moreover, the expression of the HDAC enzymes themselves can be up- or downregulated in various types of cancer.
Negative_regulation (downregulated) of Gene_expression (expression) of HDAC associated with cancer
4) Confidence 0.10 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 1.09 Pain Relevance 0
MPN and HDAC inhibitors
Negative_regulation (inhibitors) of Gene_expression (MPN) of HDAC associated with myeloproliferative disorder
5) Confidence 0.09 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.85 Pain Relevance 0

General Comments

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