INT234463

Context Info Confidence 0.34 First Reported 2008 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 23 Total Number 24 Disease Relevance 14.56 Pain Relevance 0.39

nucleoplasm (NR1H4) signal transduction (NR1H4) nucleus (NR1H4)

Anatomy Link Frequency colon 1 NR1H4 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 18 93.20 agonist 384 92.68 Inflammation 67 69.12 metalloproteinase 42 50.00 Inflammatory response 20 35.04 cINOD 20 14.80 rheumatoid arthritis 15 5.00 Osteoarthritis 15 5.00 Arthritis 9 5.00 Pain 3 5.00

Disease Link Frequency Relevance Heat Colon Cancer 380 99.68 Carcinoma 280 99.24 Apoptosis 267 99.24 Rheumatoid Arthritis 381 99.20 Cancer 659 99.04 Immunotherapy Of Cancer 40 97.84 Disease 38 96.32 Stress 20 91.84 Reprotox - General 3 20 91.64 Leukemia 103 91.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

-induced MMP production and only a singly SUMOylated form of RXR persists when IL-1?

Phosphorylation (form) of RXR

1) Confidence 0.34 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0

To address this point, we analyzed the protein sequence of RXR?

Spec (analyzed) Phosphorylation (sequence) of RXR

2) Confidence 0.34 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0

after ligand pretreatment, only the singly SUMO1-ylated form of RXR is seen (lanes 6P, 7P, and 8P).

Phosphorylation (form) of RXR

3) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0.08

that phosphorylation of RXR?

Phosphorylation (phosphorylation) of RXR

4) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.69 Pain Relevance 0

Recent studies indicate that the phosphorylation of RXR?

Phosphorylation (phosphorylation) of RXR

5) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.64 Pain Relevance 0

Phosphorylation at serine 260 of RXR?

Phosphorylation (Phosphorylation) of RXR

6) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.98 Pain Relevance 0

In addition, the phosphorylated form of RXR?

Phosphorylation (phosphorylated) of RXR

7) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.87 Pain Relevance 0

aberrant phosphorylation of retinoid X receptor (RXR), which is a heterodimeric

Phosphorylation (phosphorylation) of RXR

8) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.66 Pain Relevance 0.06

What are the precise mechanisms by which phosphorylation of RXR?

Phosphorylation (phosphorylation) of RXR

9) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.71 Pain Relevance 0

The phosphorylation of RXR?

Phosphorylation (phosphorylation) of RXR

10) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.74 Pain Relevance 0

The phosphorylation of RXR?

Phosphorylation (phosphorylation) of RXR

11) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.28 Pain Relevance 0

/RXR heterodimer by their respective ligands synergistically inhibits cell growth, while inducing apoptosis in human colon cancer cells when the phosphorylation of RXR?

Phosphorylation (phosphorylation) of RXR in colon associated with colon cancer and apoptosis

12) Confidence 0.27 Published 2008 Journal PPAR Research Section Abstract Doc Link PMC2408709 Disease Relevance 0.50 Pain Relevance 0

However, phosphorylation of RXR?

Phosphorylation (phosphorylation) of RXR

13) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.27 Pain Relevance 0.12

accumulation of the phosphorylated (i.e., inactivated) form of RXR?

Phosphorylation (phosphorylated) of RXR

14) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.99 Pain Relevance 0

The phosphorylation of RXR?

Phosphorylation (phosphorylation) of RXR

15) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.45 Pain Relevance 0

accumulation of the phosphorylated (i.e., inactivated) form of RXR?

Phosphorylation (phosphorylated) of RXR

16) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.99 Pain Relevance 0

The significance of the restoration of RXR?

Phosphorylation (restoration) of RXR

17) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.66 Pain Relevance 0

In addition, the phosphorylated form of RXR?

Phosphorylation (form) of RXR

18) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.86 Pain Relevance 0

PHOSPHORYLATED RXR?

Phosphorylation (PHOSPHORYLATED) of RXR

19) Confidence 0.23 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.45 Pain Relevance 0.03

the specific roles of the aberrant phosphorylation of RXR?

Phosphorylation (phosphorylation) of RXR

20) Confidence 0.20 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.84 Pain Relevance 0

General Comments

This test has worked.