INT234463

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 14.56
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR1H4) signal transduction (NR1H4) nucleus (NR1H4)
Anatomy Link Frequency
colon 1
NR1H4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 18 93.20 High High
agonist 384 92.68 High High
Inflammation 67 69.12 Quite High
metalloproteinase 42 50.00 Quite Low
Inflammatory response 20 35.04 Quite Low
cINOD 20 14.80 Low Low
rheumatoid arthritis 15 5.00 Very Low Very Low Very Low
Osteoarthritis 15 5.00 Very Low Very Low Very Low
Arthritis 9 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 380 99.68 Very High Very High Very High
Carcinoma 280 99.24 Very High Very High Very High
Apoptosis 267 99.24 Very High Very High Very High
Rheumatoid Arthritis 381 99.20 Very High Very High Very High
Cancer 659 99.04 Very High Very High Very High
Immunotherapy Of Cancer 40 97.84 Very High Very High Very High
Disease 38 96.32 Very High Very High Very High
Stress 20 91.84 High High
Reprotox - General 3 20 91.64 High High
Leukemia 103 91.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-induced MMP production and only a singly SUMOylated form of RXR persists when IL-1?
Phosphorylation (form) of RXR
1) Confidence 0.34 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
To address this point, we analyzed the protein sequence of RXR?
Spec (analyzed) Phosphorylation (sequence) of RXR
2) Confidence 0.34 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
after ligand pretreatment, only the singly SUMO1-ylated form of RXR is seen (lanes 6P, 7P, and 8P).
Phosphorylation (form) of RXR
3) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0.08
that phosphorylation of RXR?
Phosphorylation (phosphorylation) of RXR
4) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.69 Pain Relevance 0
Recent studies indicate that the phosphorylation of RXR?
Phosphorylation (phosphorylation) of RXR
5) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.64 Pain Relevance 0
Phosphorylation at serine 260 of RXR?
Phosphorylation (Phosphorylation) of RXR
6) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.98 Pain Relevance 0
In

addition, the phosphorylated form of RXR?

Phosphorylation (phosphorylated) of RXR
7) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.87 Pain Relevance 0
aberrant phosphorylation of retinoid X receptor (RXR), which is a heterodimeric
Phosphorylation (phosphorylation) of RXR
8) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.66 Pain Relevance 0.06
What are the precise mechanisms by which phosphorylation of RXR?
Phosphorylation (phosphorylation) of RXR
9) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.71 Pain Relevance 0
The

phosphorylation of RXR?

Phosphorylation (phosphorylation) of RXR
10) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.74 Pain Relevance 0
The phosphorylation of RXR?
Phosphorylation (phosphorylation) of RXR
11) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.28 Pain Relevance 0
/RXR heterodimer by their respective ligands synergistically inhibits cell growth, while inducing apoptosis in human colon cancer cells when the phosphorylation of RXR?
Phosphorylation (phosphorylation) of RXR in colon associated with colon cancer and apoptosis
12) Confidence 0.27 Published 2008 Journal PPAR Research Section Abstract Doc Link PMC2408709 Disease Relevance 0.50 Pain Relevance 0
However, phosphorylation of RXR?
Phosphorylation (phosphorylation) of RXR
13) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.27 Pain Relevance 0.12
accumulation of the phosphorylated (i.e., inactivated) form of RXR?
Phosphorylation (phosphorylated) of RXR
14) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.99 Pain Relevance 0
The phosphorylation of RXR?
Phosphorylation (phosphorylation) of RXR
15) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.45 Pain Relevance 0
accumulation of the phosphorylated (i.e., inactivated) form of RXR?
Phosphorylation (phosphorylated) of RXR
16) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.99 Pain Relevance 0
The

significance of the restoration of RXR?

Phosphorylation (restoration) of RXR
17) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.66 Pain Relevance 0
In

addition, the phosphorylated form of RXR?

Phosphorylation (form) of RXR
18) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.86 Pain Relevance 0
PHOSPHORYLATED RXR?
Phosphorylation (PHOSPHORYLATED) of RXR
19) Confidence 0.23 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.45 Pain Relevance 0.03
the specific roles of the aberrant phosphorylation of RXR?
Phosphorylation (phosphorylation) of RXR
20) Confidence 0.20 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.84 Pain Relevance 0

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