INT234464

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.54
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR1H4) signal transduction (NR1H4) nucleus (NR1H4)
Anatomy Link Frequency
liver 1
NR1H4 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 96 95.12 Very High Very High Very High
cytokine 6 67.00 Quite High
metalloproteinase 14 50.00 Quite Low
Arthritis 3 48.12 Quite Low
Inflammation 19 43.52 Quite Low
cINOD 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
Osteoarthritis 5 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunotherapy Of Cancer 10 97.88 Very High Very High Very High
Rheumatoid Arthritis 90 94.16 High High
Carcinoma 70 93.12 High High
Chondrosarcoma 6 92.24 High High
Cancer 162 91.80 High High
Disease 7 88.88 High High
Congenital Anomalies 5 83.76 Quite High
Hepatocellular Cancer 5 79.52 Quite High
Apoptosis 55 74.00 Quite High
Skin Cancer 10 62.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The above findings support the possibility that the inhibition of RXR?
Negative_regulation (inhibition) of RXR
1) Confidence 0.19 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.44 Pain Relevance 0.04
and the inhibition of RXR?
Negative_regulation (inhibition) of RXR
2) Confidence 0.19 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.93 Pain Relevance 0
by inactivating the Ras-Erk signaling system and thereby inhibiting RXR?
Negative_regulation (inhibiting) of RXR
3) Confidence 0.19 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.58 Pain Relevance 0.05
While RXR is an obligate dimer partner for a number of other NHRs, including retinoic acid receptors, thyroid receptor, vitamin D receptor, PPARs, liver X receptors (LXRs), and farnesoid X receptor (FXR) [22], the ligand LG268 activates only a subset of the RXR catalog of partners, including RXR:FXR, RXR:LXR, RXR:PPAR?
Negative_regulation (number) of farnesoid X receptor in liver
4) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.09 Pain Relevance 0.03
LBD impairs the transcriptional activity of RXR/RAR [21, 22] and RXR/vitamin D3 receptor (VDR) [23].
Negative_regulation (impairs) of RXR
5) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.75 Pain Relevance 0
LBD impairs the transcriptional activity of RXR/RAR [21, 22] and RXR/vitamin D3 receptor (VDR) [23].
Negative_regulation (impairs) of RXR
6) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.74 Pain Relevance 0

General Comments

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