INT234467

Context Info Confidence 0.34 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 4 Disease Relevance 0.82 Pain Relevance 0

nucleoplasm (U2AF2) mRNA processing (U2AF2) RNA binding (U2AF2) nucleus (U2AF2) enzyme binding (U2AF2)

U2AF2 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 19 5.00 Central nervous system 9 5.00 Inflammation 5 5.00 cINOD 4 5.00 Inflammatory response 1 5.00

Disease Link Frequency Relevance Heat Disease 61 71.12 Motor Neuron Diseases 12 61.00 Rheumatoid Arthritis 17 59.84 Apoptosis 11 34.32 Tauopathy 54 16.48 Cancer 32 11.32 Supranuclear Palsy 45 5.00 Spinal Muscular Atrophy 24 5.00 Colon Cancer 19 5.00 Neurodegenerative Disease 15 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The large subunit of splicing factor U2AF binds to the polypyrimidine tract while SF1 interacts with the branch site [16].

U2AF Binding (binds) of

1) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0.30 Pain Relevance 0

SR proteins, on the other hand, function as trans-splicing factors that facilitate the interaction of U1 snRNP with the 5' splice site, and the assembly of spliceosomes. through interactions with U2AF [17], SF1, and other splicing factors.

U2AF Binding (interactions) of

2) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0.16 Pain Relevance 0

The large subunit of splicing factor U2AF binds to the polypyrimidine tract while SF1 interacts with the branch site [16].

U2AF Binding (interacts) of

3) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0.30 Pain Relevance 0

for the binding of small, lipophilic molecules, a transactivation domain (AF-2

AF-2 Binding (binding) of

4) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.06 Pain Relevance 0

General Comments

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