INT234467

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.82
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (U2AF2) mRNA processing (U2AF2) RNA binding (U2AF2)
nucleus (U2AF2) enzyme binding (U2AF2)
U2AF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 19 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 61 71.12 Quite High
Motor Neuron Diseases 12 61.00 Quite High
Rheumatoid Arthritis 17 59.84 Quite High
Apoptosis 11 34.32 Quite Low
Tauopathy 54 16.48 Low Low
Cancer 32 11.32 Low Low
Supranuclear Palsy 45 5.00 Very Low Very Low Very Low
Spinal Muscular Atrophy 24 5.00 Very Low Very Low Very Low
Colon Cancer 19 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The large subunit of splicing factor U2AF binds to the polypyrimidine tract while SF1 interacts with the branch site [16].
U2AF Binding (binds) of
1) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0.30 Pain Relevance 0
SR proteins, on the other hand, function as trans-splicing factors that facilitate the interaction of U1 snRNP with the 5' splice site, and the assembly of spliceosomes. through interactions with U2AF [17], SF1, and other splicing factors.
U2AF Binding (interactions) of
2) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0.16 Pain Relevance 0
The large subunit of splicing factor U2AF binds to the polypyrimidine tract while SF1 interacts with the branch site [16].
U2AF Binding (interacts) of
3) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0.30 Pain Relevance 0
for the binding of small, lipophilic molecules, a transactivation domain (AF-2
AF-2 Binding (binding) of
4) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.06 Pain Relevance 0

General Comments

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