INT234468

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.87
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR1H4) signal transduction (NR1H4) nucleus (NR1H4)
NR1H4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 98.36 Very High Very High Very High
agonist 20 50.00 Quite Low
metalloproteinase 14 50.00 Quite Low
Inflammation 11 22.48 Low Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
Osteoarthritis 5 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 34 96.28 Very High Very High Very High
Carcinoma 14 87.36 High High
Congenital Anomalies 1 59.32 Quite High
Disease 3 49.00 Quite Low
Rheumatoid Arthritis 22 26.48 Quite Low
INFLAMMATION 14 22.48 Low Low
Chondrosarcoma 6 13.68 Low Low
Colon Cancer 19 7.60 Low Low
Apoptosis 11 5.00 Very Low Very Low Very Low
Leukemia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
inhibitors restores the degradation of RXR?
Protein_catabolism (degradation) of RXR
1) Confidence 0.32 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.87 Pain Relevance 0
This suggests that treatment with a proinflammatory cytokine may activate pathways that cause removal of SUMO1 from conjugated RXR or perhaps degradation of doubly SUMO1-ylated RXR (see Discussion).
Protein_catabolism (degradation) of RXR associated with cytokine
2) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0.09

General Comments

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