INT234490

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.34
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maoa) oxidoreductase activity (Maoa)
Anatomy Link Frequency
lung 1
ND3 1
Maoa (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 6 99.12 Very High Very High Very High
alcohol 1 98.90 Very High Very High Very High
Nicotine 2 98.64 Very High Very High Very High
Neurotransmitter 2 81.68 Quite High
Inflammation 1 71.92 Quite High
monoamine 8 50.00 Quite Low
Serotonin 3 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
opioid receptor 2 5.00 Very Low Very Low Very Low
sSRI 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 94 99.20 Very High Very High Very High
Cancer 17 98.80 Very High Very High Very High
Lung Cancer 3 98.08 Very High Very High Very High
Parkinson's Disease 2 96.44 Very High Very High Very High
Metastasis 5 96.32 Very High Very High Very High
Infection 36 92.04 High High
Nicotine Addiction 171 88.56 High High
INFLAMMATION 2 71.92 Quite High
Disease 8 64.44 Quite High
Flavivirus Infection 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A higher methylation of MAOA has been found associated with nicotine- and alcohol-dependence [40] in women whereas a down-regulation of MAOA transcription has been reported in several cancers including lung cancer [41].
Transcription (transcription) of MAOA in lung associated with addiction, lung cancer, cancer, nicotine and alcohol
1) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.15 Pain Relevance 0.23
Indeed, they attributed that the improvement in the motor weakness was probably due to the MAO inhibitory activity of isatin and suggested that isatin could possibly serve as a new therapeutic agent for Parkinsonism.
Transcription (activity) of MAO associated with parkinson's disease
2) Confidence 0.22 Published 2008 Journal Virol J Section Body Doc Link PMC2408923 Disease Relevance 0.36 Pain Relevance 0.04
Expression profiles of genes in CRPC support a role for the transcriptional activity of the androgen receptor (CCNH, CUEDC2, FLNA, PSMA7), steroid synthesis and metabolism (DHCR24, DHRS7, ELOVL5, HSD17B4, OPRK1), neuroendocrine (ENO2, MAOA, OPRK1, S100A10, TRPM8), and proliferation (GAS5, GNB2L1, MT-ND3, NKX3-1, PCGEM1, PTGFR, STEAP1, TMEM30A), but neither supported nor discounted a role for cell survival genes.


Transcription (activity) of MAOA in ND3 associated with reprotox - general 1
3) Confidence 0.12 Published 2010 Journal BMC Med Genomics Section Abstract Doc Link PMC2956710 Disease Relevance 0.83 Pain Relevance 0

General Comments

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