INT234493

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.87
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 1
plaques 1
sch (Mus musculus)
Pain Link Frequency Relevance Heat
Lasting pain 2 89.92 High High
Migraine 166 88.12 High High
headache 24 75.68 Quite High
Pain 5 72.56 Quite High
Fibrositis 4 46.08 Quite Low
depression 19 20.80 Low Low
Cluster headache 1 10.40 Low Low
agonist 10 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 17 98.84 Very High Very High Very High
Death 12 97.60 Very High Very High Very High
Paralysis 3 97.20 Very High Very High Very High
Epilepsy 17 96.84 Very High Very High Very High
Infection 108 96.48 Very High Very High Very High
Stress 6 96.24 Very High Very High Very High
Scotoma 1 95.24 Very High Very High Very High
Toxicity 6 95.00 High High
Pain 6 89.92 High High
Headache 151 88.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The therapeutic potential of SCH 16 was also evaluated using a peripheral challenge model wherein JEV (50LD50) was injected (200 ?
Gene_expression (therapeutic) of SCH
1) Confidence 0.67 Published 2008 Journal Virol J Section Body Doc Link PMC2408923 Disease Relevance 0.58 Pain Relevance 0
To determine the in vivo antiviral potential of SCH 16, three groups of mice (4 mice per group) were injected intracerebrally with 30 ?
Gene_expression (antiviral) of SCH
2) Confidence 0.67 Published 2008 Journal Virol J Section Body Doc Link PMC2408923 Disease Relevance 0.45 Pain Relevance 0
It was noted that SCH 16 and Ribavirin exhibited a dose depended reduction of plaques formed by JEV and WNV (Figure 2, Panels A and B) with an IC50 of 16 ?
Gene_expression (exhibited) of SCH in plaques
3) Confidence 0.67 Published 2008 Journal Virol J Section Body Doc Link PMC2408923 Disease Relevance 0.11 Pain Relevance 0
Contextually, the other hypothalamic areas of NHIB continued to maintain notably high expression capacities of this specific subunit as shown by very strong and moderately higher (p < 0.05) levels in Arc and Pe, respectively, while very strong levels, instead, characterized Sch of HIBs.
Gene_expression (characterized) of Sch associated with aids-related complex
4) Confidence 0.09 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2944354 Disease Relevance 0.53 Pain Relevance 0
Intriguingly, one of the genes in this region, SCH3, is highly expressed in occipital and temporal lobes, and regulates the neuronal adaptation against environmental stress (Troglio et al., 2004).


Gene_expression (expressed) of SCH3 in neuronal associated with stress
5) Confidence 0.06 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3008936 Disease Relevance 2.21 Pain Relevance 1.22

General Comments

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