INT234494

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 2.47
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Syp) protein complex (Syp)
Anatomy Link Frequency
molecular layer 1
neurons 1
endocrine cells 1
dopaminergic neurons 1
Syp (Mus musculus)
Syp - S129A (1)
Pain Link Frequency Relevance Heat
Somatostatin 5 97.76 Very High Very High Very High
Serotonin 6 97.20 Very High Very High Very High
GABAergic 1 92.32 High High
Substantia nigra 64 90.16 High High
gABA 9 76.84 Quite High
Dopamine 140 75.84 Quite High
Neurobehavioral 1 64.32 Quite High
midbrain 34 55.76 Quite High
Abeta 1 50.00 Quite Low
Neuritis 1 45.96 Quite Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 185 99.18 Very High Very High Very High
Aging 23 98.88 Very High Very High Very High
Disease 82 96.20 Very High Very High Very High
Aids-related Complex 4 94.48 High High
Targeted Disruption 88 92.08 High High
Cyst 23 88.04 High High
Apoptosis 23 86.76 High High
Choristoma 6 78.08 Quite High
Retts Disease 68 73.36 Quite High
Stress 20 59.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S129A mutant a-Syn was generated by PCR using established methods (45) in which we used human WT a-Syn and 5?
Positive_regulation (generated) of Syn
1) Confidence 0.65 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.24 Pain Relevance 0
An important clue from our current studies is the discovery that as a-Syn levels increase in MN9D cells, Ser(P)-129 levels also increased (Fig. 5).
Positive_regulation (increase) of Syn
2) Confidence 0.65 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.30 Pain Relevance 0
A recent report in transduced MN9D cells overexpressing the a-Syn S129D phosphomimic saw an increase in TH-Ser(P)-40 phosphorylation (107).
Positive_regulation (increase) of Syn
3) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.27 Pain Relevance 0.04
2–3-fold increase in a-Syn levels in nigral neurons (62).
Positive_regulation (increase) of Syn in neurons
4) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.27 Pain Relevance 0.03
On the contrary, control wild type mice subjected to EE showed the expected elevation in synaptophysin levels.
Positive_regulation (elevation) of synaptophysin
5) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.19 Pain Relevance 0.03
These data contrast with the observed upregulation of synaptophysin in the littermate wild type controls housed together with the Mecp2?
Positive_regulation (upregulation) of synaptophysin
6) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.16 Pain Relevance 0
The endocrine cells were also positive for their typical markers chromogranin A, synaptophysin and beta-endorphin.
Positive_regulation (positive) of synaptophysin in endocrine cells
7) Confidence 0.45 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2408929 Disease Relevance 0.25 Pain Relevance 0.40
Using WT-Syn lentivirus in ASKO mice, we previously showed that TH phosphorylation is reduced when soluble a-Syn levels increase in dopaminergic neurons (48).
Positive_regulation (increase) of Syn in dopaminergic neurons
8) Confidence 0.43 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.08
When we measured PP2A activity in MN9D cells, we found significantly elevated PP2A activity in both WT-Syn and S129A-Syn cells compared with GFP-transfected controls, with the largest activation of PP2A noted for S129A-Syn dephosphorylation mimic cells (Fig. 5C; p < 0.0001, one-way ANOVA).
Positive_regulation (activation) of Syn (S129A)
9) Confidence 0.43 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0
High levels of a-Syn induce pathology in families with extra copies of the a-Syn gene, as recently reviewed (104).
Positive_regulation (levels) of Syn
10) Confidence 0.43 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.32 Pain Relevance 0
Unexpectedly, quantitative determination showed that the number of synaptophysin-positive punctae was significantly increased and also synapsin I+II- and vGlut2-positive punctae tended to be increased in TGF-?
Positive_regulation (increased) of synaptophysin
11) Confidence 0.12 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.08
(25–35)-injected mice receiving vehicle, and administration of Kihi-to resulted in significant increases in synaptophysin expression levels in CA1, the oriens and radiatum in CA3, the molecular layer in dentate gyrus (Figures 5 and 7).
Positive_regulation (increases) of synaptophysin in molecular layer
12) Confidence 0.11 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.06 Pain Relevance 0
For the present study we chose to focus on DLB because of its frequency and widespread accumulation of a-syn in neocortical and limbic structures [46], [47], [48].
Positive_regulation (accumulation) of a-syn associated with parkinson's disease
13) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.41 Pain Relevance 0.03

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