INT234586

Context Info Confidence 0.41 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.23 Pain Relevance 0.14

cytosol (Ncf2) nucleolus (Ncf2) cytoplasm (Ncf2)

Ncf2 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 42 86.24 Inflammatory mediators 6 64.16 cytokine 38 53.68 Inflammatory response 12 42.24 Central nervous system 16 5.00 chemokine 16 5.00 COX-2 inhibitor 8 5.00 cINOD 8 5.00 Intracerebroventricular 6 5.00 Inflammatory stimuli 6 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 70 86.24 Neurodegenerative Disease 6 5.00 Injury 6 5.00 Stress 6 5.00 Drug Induced Neurotoxicity 6 5.00 Disease 6 5.00 Death 4 5.00 Necrosis 4 5.00 Cognitive Disorder 4 5.00 Sprains And Strains 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

COX-2-/- mice showed a higher increase in the expression of p67phox and gp91phox mRNA than COX-2+/+ mice (Fig. 5B and 5C).

Transcription (expression) of p67phox

1) Confidence 0.41 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.14 Pain Relevance 0.10

Similarly, mRNA levels of NADPH oxidase cytosolic subunit p67phox and membrane subunit gp91phox were significantly elevated at 24 h after LPS injection in both genotypes compared with vehicle-injected controls (Fig. 5B and 5C).

Transcription (levels) of p67phox

2) Confidence 0.41 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.09 Pain Relevance 0.04

General Comments

This test has worked.