INT234587

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.84
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr2) plasma membrane (Tlr2) intracellular (Tlr2)
cytoplasm (Tlr2)
Anatomy Link Frequency
microglia 4
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 41 100.00 Very High Very High Very High
Hippocampus 7 95.12 Very High Very High Very High
Paracetamol 1 93.92 High High
COX-2 inhibitor 4 84.68 Quite High
Inflammatory response 18 82.24 Quite High
rheumatoid arthritis 1 54.24 Quite High
cytokine 32 21.48 Low Low
Central nervous system 29 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
chemokine 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 67 100.00 Very High Very High Very High
Disease 59 96.64 Very High Very High Very High
Hepatotoxicity 1 94.84 High High
Ocular & Orbital Inflammation 1 91.92 High High
Targeted Disruption 9 87.48 High High
Convulsion 1 87.24 High High
Urological Neuroanatomy 16 85.64 High High
Drug Induced Neurotoxicity 9 75.68 Quite High
Parkinson's Disease 3 70.12 Quite High
Disease Progression 5 60.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reverse transcription-generated cDNA encoding TLR2, TLR4, and TNF?
Positive_regulation (generated) of Transcription (transcription) of TLR2
1) Confidence 0.36 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.14 Pain Relevance 0
Another study reported, in support of our observations, that selective pharmacological inhibition of COX-2 with NS-398 increases the transcription of inflammatory genes (mPGES-1, TLR2, CD14, MCP-1) in vascular associated brain cells and parenchymal microglia after systemic injection of LPS [14].
Positive_regulation (increases) of Transcription (transcription) of TLR2 in microglia associated with inflammation
2) Confidence 0.35 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.90 Pain Relevance 0.36
Plaque-associated microglia exhibit elevated mRNA levels for TLR2, 4, 5, 7, 9 [87] (Figure 1).
Positive_regulation (elevated) of Transcription (levels) of TLR2 in microglia
3) Confidence 0.24 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 0.80 Pain Relevance 0.14

General Comments

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