INT234591

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.17
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ncf2) nucleolus (Ncf2) cytoplasm (Ncf2)
Ncf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 12 67.80 Quite High
COX-2 inhibitor 8 66.48 Quite High
cytokine 47 61.56 Quite High
Inflammatory mediators 6 56.88 Quite High
Inflammation 48 50.72 Quite High
GABAergic 9 50.00 Quite Low
Central nervous system 17 5.00 Very Low Very Low Very Low
Hippocampus 17 5.00 Very Low Very Low Very Low
chemokine 16 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 76 67.44 Quite High
Cognitive Disorder 39 50.00 Quite Low
Stress 7 44.16 Quite Low
Aging 23 23.76 Low Low
Disease 12 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
level, NADPH oxidase subunit p67phox, and phosphorylated STAT3
Gene_expression (level) of p67phox
1) Confidence 0.52 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.12 Pain Relevance 0.09
The protein levels of p67phox (Fig. 7C and 7D) and phosphorylated STAT3 after LPS (Fig. 7E and 7F) were also higher in the celecoxib-treated mice compared to untreated mice.


Gene_expression (levels) of p67phox
2) Confidence 0.46 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.05 Pain Relevance 0.09
Nox2 requires co-assembly with not only p22phox , but its p47phox and p67phox subunits for activity, whereas Nox4 has been shown to be active in the absence of p47phox and p67phox [29].
Neg (absence) Gene_expression (absence) of p67phox
3) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0

General Comments

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