INT234597

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.25
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr2) plasma membrane (Tlr2) intracellular (Tlr2)
cytoplasm (Tlr2)
Anatomy Link Frequency
microglia 4
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 23 100.00 Very High Very High Very High
Paracetamol 1 95.20 Very High Very High Very High
cytokine 57 92.80 High High
Hippocampus 5 92.40 High High
COX-2 inhibitor 4 85.96 High High
Inflammatory response 7 83.52 Quite High
cINOD 9 58.68 Quite High
rheumatoid arthritis 1 55.52 Quite High
chemokine 27 5.00 Very Low Very Low Very Low
cerebral cortex 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 40 100.00 Very High Very High Very High
Disease 116 99.32 Very High Very High Very High
Hepatotoxicity 1 96.12 Very High Very High Very High
Disease Progression 1 95.28 Very High Very High Very High
Ocular & Orbital Inflammation 1 93.20 High High
Targeted Disruption 16 89.44 High High
Convulsion 1 88.52 High High
Amyloid Plaque 7 77.20 Quite High
Drug Induced Neurotoxicity 3 76.96 Quite High
Gliosis 3 76.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another study reported, in support of our observations, that selective pharmacological inhibition of COX-2 with NS-398 increases the transcription of inflammatory genes (mPGES-1, TLR2, CD14, MCP-1) in vascular associated brain cells and parenchymal microglia after systemic injection of LPS [14].
Negative_regulation (inhibition) of Positive_regulation (increases) of TLR2 in microglia associated with inflammation
1) Confidence 0.30 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.91 Pain Relevance 0.37
Activation of cultured microglia with toll-like receptor 2 (TLR2), TLR4, or TLR9 ligand markedly boosted ingestion of A?
Negative_regulation (boosted) of Positive_regulation (Activation) of TLR2 in microglia
2) Confidence 0.29 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.34 Pain Relevance 0.15

General Comments

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