INT234601

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.12
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Tlr4, Cpox) mitochondrion (Cpox) signal transduction (Tlr4)
oxidoreductase activity (Cpox) plasma membrane (Tlr4) intracellular (Tlr4)
Anatomy Link Frequency
Brain 1
Tlr4 (Mus musculus)
Cpox (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 6 65.04 Quite High
cytokine 19 58.80 Quite High
Inflammatory mediators 3 54.12 Quite High
COX-2 inhibitor 4 34.72 Quite Low
Inflammation 21 18.96 Low Low
Central nervous system 8 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Intracerebroventricular 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 35 64.68 Quite High
Stress 3 12.40 Low Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brain COX-1 protein levels were not significantly changed by LPS treatment either in COX-2+/+ or in celecoxib-treated mice (Fig. 7A, COX-2+/+ mice: 0.041 ± 0.009 LPS vs. 0.033 ± 0.003 vehicle; celecoxib-treated COX-2+/+ mice: 0.043 ± 0.0.008 LPS vs. 0.038 ± 0.004 vehicle; p > 0.05).
LPS Neg (not) Regulation (changed) of COX in Brain
1) Confidence 0.05 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.12 Pain Relevance 0.09

General Comments

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