INT23463

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2011
Negated 2
Speculated 0
Reported most in Abstract
Documents 47
Total Number 47
Disease Relevance 18.14
Pain Relevance 28.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
endothelial cells 12
neural 8
sensory neurons 4
immune cells 4
nerves 4
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 1066 100.00 Very High Very High Very High
antagonist 241 100.00 Very High Very High Very High
substance P 203 100.00 Very High Very High Very High
Neuropeptide 142 100.00 Very High Very High Very High
calcitonin gene related peptide 96 100.00 Very High Very High Very High
Pain 89 100.00 Very High Very High Very High
Neurotransmitter 6 100.00 Very High Very High Very High
Analgesic 5 100.00 Very High Very High Very High
Clonidine 63 99.98 Very High Very High Very High
qutenza 82 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 66 99.98 Very High Very High Very High
Heat Stress Disorders 36 99.98 Very High Very High Very High
Pain 89 99.84 Very High Very High Very High
Headache 206 99.68 Very High Very High Very High
Cluster Headache 7 99.16 Very High Very High Very High
Hypercalcemia 36 99.04 Very High Very High Very High
INFLAMMATION 313 98.80 Very High Very High Very High
Bone Cancer 1 98.48 Very High Very High Very High
Fever 6 98.16 Very High Very High Very High
Injury 34 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: These results suggest that the expression of CGRP is increased in the synovial tissues from patients with internal derangement, and that CGRP seems to play an important role in the mechanism of pain production in patients with symptomatic internal derangement.


Positive_regulation (increased) of Gene_expression (expression) of CGRP in internal
1) Confidence 0.70 Published 2004 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 15529124 Disease Relevance 0.14 Pain Relevance 0
Capsaicin increased the level of CGRP in the culture medium, and up-regulated the expression of CGRP in endothelial cells.
Positive_regulation (up-regulated) of Gene_expression (expression) of CGRP in endothelial cells associated with qutenza and calcitonin gene-related peptide
2) Confidence 0.69 Published 2008 Journal Regul. Pept. Section Abstract Doc Link 18584893 Disease Relevance 0.28 Pain Relevance 0.92
Clonidine induces calcitonin gene-related peptide expression via nitric oxide pathway in endothelial cells.
Positive_regulation (induces) of Gene_expression (expression) of calcitonin gene-related peptide in endothelial cells associated with calcitonin gene-related peptide and clonidine
3) Confidence 0.68 Published 2009 Journal Peptides Section Title Doc Link 19520131 Disease Relevance 0 Pain Relevance 1.12
These results suggest that clonidine could stimulate CGRP synthesis and secretion in endothelial cells through the activation of alpha(2)-adrenoceptor, which is related to the NO pathway.
Positive_regulation (stimulate) of Gene_expression (synthesis) of CGRP in endothelial cells associated with calcitonin gene-related peptide and clonidine
4) Confidence 0.68 Published 2009 Journal Peptides Section Abstract Doc Link 19520131 Disease Relevance 0 Pain Relevance 1.12
L-NAME treatment could also inhibit clonidine-induced CGRP synthesis and secretion concomitantly with the decreased NO content in culture medium.
Positive_regulation (induced) of Gene_expression (synthesis) of CGRP associated with calcitonin gene-related peptide and clonidine
5) Confidence 0.68 Published 2009 Journal Peptides Section Abstract Doc Link 19520131 Disease Relevance 0 Pain Relevance 1.17
The present study was to determine whether clonidine could induce calcitonin gene-related peptide (CGRP) production and the underlying mechanisms.
Positive_regulation (induce) of Gene_expression (production) of CGRP associated with calcitonin gene-related peptide and clonidine
6) Confidence 0.68 Published 2009 Journal Peptides Section Abstract Doc Link 19520131 Disease Relevance 0 Pain Relevance 0.76
And heat stress increased the expression of CGRP, which was also abolished by capsazepine.
Positive_regulation (increased) of Gene_expression (expression) of CGRP associated with heat stress disorders and calcitonin gene-related peptide
7) Confidence 0.68 Published 2007 Journal Vascul. Pharmacol. Section Abstract Doc Link 17140857 Disease Relevance 0.71 Pain Relevance 0.71
Indeed, activation of mitogen-activated protein kinase pathways can increase CGRP neuropeptide synthesis and secretion.
Positive_regulation (increase) of Gene_expression (synthesis) of CGRP associated with neuropeptide and calcitonin gene-related peptide
8) Confidence 0.67 Published 2002 Journal Pharmacol. Ther. Section Abstract Doc Link 12191595 Disease Relevance 0.99 Pain Relevance 1.33
CONCLUSION: CGRP receptor expression in human pulp tissue is significantly increased during inflammatory phenomena such as acute irreversible pulpitis.


Positive_regulation (increased) of Gene_expression (expression) of CGRP
9) Confidence 0.67 Published 2005 Journal Int Endod J Section Body Doc Link 16164685 Disease Relevance 0.12 Pain Relevance 0
Administration of rutaecarpine reversed EPC senescence along with an elevation in CGRP production in spontaneously hypertensive rats.
Positive_regulation (elevation) of Gene_expression (production) of CGRP
10) Confidence 0.66 Published 2010 Journal J. Hypertens. Section Body Doc Link 20375903 Disease Relevance 0.14 Pain Relevance 0
Moreover, rutaecarpine, as an agent or tool to stimulate CGRP production, was used in hypertensive animals.
Positive_regulation (stimulate) of Gene_expression (production) of CGRP
11) Confidence 0.66 Published 2010 Journal J. Hypertens. Section Body Doc Link 20375903 Disease Relevance 0.17 Pain Relevance 0
We also assessed the functionality of these leucine CLR mutants to increase the CGRP mediated production of cAMP in an effort to understand the importance of these receptor residues for agonist-dependent activation.
Positive_regulation (mediated) of Gene_expression (production) of CGRP associated with agonist and calcitonin gene-related peptide
12) Confidence 0.62 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.59
However, the potency of these modified ligands was significantly less when compared to CGRP mediated production of cAMP from the same wild type receptor, which is directly related to loss of the phenylalaninamide.
Positive_regulation (mediated) of Gene_expression (production) of CGRP associated with calcitonin gene-related peptide and potency
13) Confidence 0.62 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.71
We also assessed the functionality of these leucine CLR mutants to increase the CGRP mediated production of cAMP in an effort to understand the importance of these receptor residues for agonist-dependent activation.
Positive_regulation (increase) of Gene_expression (production) of CGRP associated with agonist and calcitonin gene-related peptide
14) Confidence 0.62 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.59
Overexpression and purification of recombinant eel calcitonin and its phylogenetic analysis.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of eel calcitonin
15) Confidence 0.61 Published 2005 Journal Protein Pept. Lett. Section Title Doc Link 15777276 Disease Relevance 0.47 Pain Relevance 0.09
These results suggest that synthetic human calcitonin is highly effective on pain and functional impairment in bone disease and is well tolerated.
Positive_regulation (effective) of Gene_expression (synthetic) of calcitonin associated with pain and bone cancer
16) Confidence 0.50 Published 1985 Journal J. Int. Med. Res. Section Abstract Doc Link 2416607 Disease Relevance 0.91 Pain Relevance 0.52
The CGRP-1, antagonist human alpha-CGRP8-37 blocked the response to human alpha-CGRP but not to human beta-CGRP, while the putative antagonist [Tyr]CGRP28-37 did not.
Positive_regulation (response) of Neg (blocked) Gene_expression (blocked) of CGRP-1 associated with antagonist and calcitonin gene-related peptide
17) Confidence 0.50 Published 1996 Journal Cephalalgia Section Abstract Doc Link 8869765 Disease Relevance 0.07 Pain Relevance 0.83
Transient receptor potential vanilloid 1-mediated expression and secretion of endothelial cell-derived calcitonin gene-related peptide.
Positive_regulation (1-mediated) of Gene_expression (expression) of calcitonin gene-related peptide in endothelial cell associated with qutenza and calcitonin gene-related peptide
18) Confidence 0.50 Published 2008 Journal Regul. Pept. Section Title Doc Link 18584893 Disease Relevance 0.21 Pain Relevance 0.92
The study showed that clonidine was able to induce CGRP mRNA (alpha- and beta-isoforms) expression in a dose-dependent manner in endothelial cells.
Positive_regulation (induce) of Gene_expression (expression) of CGRP in endothelial cells associated with calcitonin gene-related peptide and clonidine
19) Confidence 0.49 Published 2009 Journal Peptides Section Abstract Doc Link 19520131 Disease Relevance 0 Pain Relevance 1.21
The present study was to determine whether clonidine could induce calcitonin gene-related peptide (CGRP) production and the underlying mechanisms.
Positive_regulation (induce) of Gene_expression (production) of calcitonin gene-related peptide associated with calcitonin gene-related peptide and clonidine
20) Confidence 0.49 Published 2009 Journal Peptides Section Abstract Doc Link 19520131 Disease Relevance 0 Pain Relevance 0.76

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