INT23465

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Context Info
Confidence 0.76
First Reported 1985
Last Reported 2010
Negated 1
Speculated 6
Reported most in Body
Documents 31
Total Number 37
Disease Relevance 15.09
Pain Relevance 6.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100b) nucleus (S100b) cytoplasm (S100b)
Anatomy Link Frequency
brain 6
astrocytes 4
CSF 3
neuronal 3
sciatic nerve 2
S100b (Rattus norvegicus)
S100b - S100P (2)
Pain Link Frequency Relevance Heat
anesthesia 32 99.96 Very High Very High Very High
Sciatic nerve 165 99.84 Very High Very High Very High
cytokine 31 99.84 Very High Very High Very High
Multiple sclerosis 10 99.64 Very High Very High Very High
Migraine 20 99.52 Very High Very High Very High
dorsal root ganglion 108 99.48 Very High Very High Very High
headache 4 99.16 Very High Very High Very High
Action potential 24 96.44 Very High Very High Very High
cva 12 94.24 High High
tetrodotoxin 11 93.60 High High
Disease Link Frequency Relevance Heat
Sepsis 32 99.68 Very High Very High Very High
Demyelinating Disease 10 99.64 Very High Very High Very High
Headache 24 99.52 Very High Very High Very High
Ganglion Cysts 108 99.48 Very High Very High Very High
Endotoxemia 6 99.32 Very High Very High Very High
Skin Cancer 5 99.32 Very High Very High Very High
Myocardial Infarction 42 98.96 Very High Very High Very High
Neuropathic Pain 55 98.20 Very High Very High Very High
Disease 99 97.28 Very High Very High Very High
Central Nervous System Lupus Vasculitis 4 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The focal glial S100B expression was more intense in the endotoxemic pigs than in controls (P = 0.0047).
Gene_expression (expression) of S100B
1) Confidence 0.76 Published 2010 Journal Anesth. Analg. Section Body Doc Link 19897802 Disease Relevance 0.06 Pain Relevance 0
RESULTS: Total and degraded GFAP content and S100B protein expression in different areas of brain tissues significantly increased in diabetic rats compared to control rats.
Gene_expression (expression) of S100B protein in brain
2) Confidence 0.76 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15780189 Disease Relevance 0.08 Pain Relevance 0
S100B is a calcium-binding protein, produced and secreted by astrocytes, which has a putative paracrine neurotrophic activity.
Gene_expression (produced) of S100B in astrocytes
3) Confidence 0.75 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18582527 Disease Relevance 0 Pain Relevance 0.32
We therefore investigated the correlation between serum S100B levels and those of the specific cardiac marker troponin I in order to assess the cerebral vs. extracerebral origin of S100B.
Gene_expression (levels) of S100B
4) Confidence 0.74 Published 2004 Journal Anaesthesia Section Abstract Doc Link 15023104 Disease Relevance 0.07 Pain Relevance 0.06
The glial classification of RT4-D is based on the syntheses of S100P and GFAP.
Gene_expression (syntheses) of S100P (S100P) in RT4
5) Confidence 0.67 Published 1985 Journal Dev. Biol. Section Abstract Doc Link 2416613 Disease Relevance 0 Pain Relevance 0.22
In addition, these neuronal cell types do not synthesize two glial proteins, S100 protein (S100P) and glial fibrillary acidic protein (GFAP).
Neg (not) Gene_expression (synthesize) of S100P (S100P) in neuronal
6) Confidence 0.67 Published 1985 Journal Dev. Biol. Section Abstract Doc Link 2416613 Disease Relevance 0 Pain Relevance 0.22
S100B is present not only in the brain but also in other tissues.
Gene_expression (present) of S100B in brain
7) Confidence 0.67 Published 2010 Journal Anesth. Analg. Section Abstract Doc Link 19897802 Disease Relevance 0.36 Pain Relevance 0
Recently, it was shown that S100B, a subunit of the S100 protein family, is detectable in the serum of melanoma patients and correlates with the stage of the disease in patients with metastatic melanoma.
Gene_expression (detectable) of S100B associated with disease and skin cancer
8) Confidence 0.65 Published 1999 Journal Br. J. Dermatol. Section Abstract Doc Link 10354072 Disease Relevance 0.60 Pain Relevance 0
In this study, we investigated the levels of s100b and NSE in adult migraineurs during and after migraine attacks in order to gain some more insight into migraine pathophysiology.
Spec (investigated) Gene_expression (levels) of s100b associated with migraine
9) Confidence 0.59 Published 2009 Journal Headache Section Abstract Doc Link 18783450 Disease Relevance 0.37 Pain Relevance 0.37
METHODS: Serum levels of s100b and NSE were measured in 21 migraineurs and compared with 21 healthy subjects matched by sex and age.
Gene_expression (levels) of s100b
10) Confidence 0.59 Published 2009 Journal Headache Section Body Doc Link 18783450 Disease Relevance 0.10 Pain Relevance 0
The levels of GFAP, S100B, and NSE were determined by immunoblotting in the hippocampus, cortex, and cerebellum.
Spec (determined) Gene_expression (levels) of S100B in cerebellum
11) Confidence 0.59 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15780189 Disease Relevance 0.09 Pain Relevance 0
Mean superior sagittal sinus S100B concentrations were higher than mean arterial concentrations at all time points in the endotoxemic animals; however, significance was only reached at 2 h (P = 0.033).
Gene_expression (concentrations) of S100B in superior sagittal sinus
12) Confidence 0.58 Published 2010 Journal Anesth. Analg. Section Body Doc Link 19897802 Disease Relevance 0.06 Pain Relevance 0
Our aim in this study was to determine whether the brain is an important source of S100B in an experimental sepsis model.
Gene_expression (source) of S100B in brain associated with sepsis
13) Confidence 0.52 Published 2010 Journal Anesth. Analg. Section Abstract Doc Link 19897802 Disease Relevance 0.45 Pain Relevance 0
The brain is a source of S100B increase during endotoxemia in the pig.
Gene_expression (source) of S100B in brain associated with endotoxemia and anesthesia
14) Confidence 0.52 Published 2010 Journal Anesth. Analg. Section Title Doc Link 19897802 Disease Relevance 0.37 Pain Relevance 0.10
CONCLUSIONS: Our results support the hypothesis that the brain is an important source of S100B in endotoxemia even though there may be other sources.
Gene_expression (source) of S100B in brain
15) Confidence 0.52 Published 2010 Journal Anesth. Analg. Section Body Doc Link 19897802 Disease Relevance 0 Pain Relevance 0
Additionally, we were able to detect strong expression of s100B, a Schwann cell marker, in both sciatic nerve and DRG cultures, with Ct values ranging from 26–30.
Gene_expression (expression) of s100B in sciatic nerve associated with dorsal root ganglion and sciatic nerve
16) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.55 Pain Relevance 0.63
Cells cultured from both naïve DRG and sciatic nerve showed expression of s100B, confirming the presence of Schwann and/or satellite 'glial' cells.
Gene_expression (expression) of s100B in sciatic nerve associated with dorsal root ganglion and sciatic nerve
17) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.65 Pain Relevance 0.40
Interestingly, although s100B expression was strong in nerve cultures, it was still stronger in DRG cultures (Fig. 5E).


Gene_expression (expression) of s100B in nerve associated with dorsal root ganglion
18) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.52 Pain Relevance 0.60
Other possible explanations concerning the detected serum levels of s100b and NSE will be discussed; however, neuronal cell death can be ruled out by the decreased serum concentrations of NSE.
Gene_expression (levels) of s100b in neuronal
19) Confidence 0.46 Published 2009 Journal Headache Section Body Doc Link 18783450 Disease Relevance 0.07 Pain Relevance 0
Serum concentrations of s100b and NSE in migraine.
Gene_expression (concentrations) of s100b associated with migraine
20) Confidence 0.46 Published 2009 Journal Headache Section Title Doc Link 18783450 Disease Relevance 0.27 Pain Relevance 0.36

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