INT234676

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 6
Speculated 4
Reported most in Body
Documents 4
Total Number 53
Disease Relevance 63.59
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (SNCG) microtubule organizing center (SNCG) cytoplasm (SNCG)
Anatomy Link Frequency
colon 10
epithelium 3
endothelial cells 1
smooth muscle cells 1
lung 1
SNCG (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 36 54.40 Quite High
palliative 49 53.08 Quite High
ischemia 18 40.16 Quite Low
beta blocker 4 29.28 Quite Low
imagery 19 5.00 Very Low Very Low Very Low
Electroencephalography 8 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Transcranial magnetic stimulation 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 2500 100.00 Very High Very High Very High
Breast Cancer 588 100.00 Very High Very High Very High
Malignant Neoplastic Disease 196 100.00 Very High Very High Very High
Hyperplasia 147 99.98 Very High Very High Very High
Adenocarcinoma 196 99.92 Very High Very High Very High
Colon Cancer 2548 99.88 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 49 99.64 Very High Very High Very High
Disease 393 99.60 Very High Very High Very High
Recurrence 1275 99.44 Very High Very High Very High
Glioma 49 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar studies also demonstrated that SNCG expression was stage-specific in many different cancer types [15].
Gene_expression (expression) of SNCG associated with cancer
1) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.40 Pain Relevance 0
Associations between SNCG expression and clinical and biological tumor characteristics were analyzed (Table 1).
Gene_expression (expression) of SNCG associated with cancer
2) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.60 Pain Relevance 0
While 71.4% of advanced breast cancers are positive for SNCG expression, only 26.8% of stage I/II breast cancers are positive for SNCG expression and 5.2% of benign hyperplasia expresses SNCG.
Gene_expression (expression) of SNCG associated with breast cancer, advanced or metastatic breast cancer and hyperplasia
3) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.85 Pain Relevance 0
While 71.4% of advanced breast cancers are positive for SNCG expression, only 26.8% of stage I/II breast cancers are positive for SNCG expression and 5.2% of benign hyperplasia expresses SNCG.
Gene_expression (expression) of SNCG associated with breast cancer, advanced or metastatic breast cancer and hyperplasia
4) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.71 Pain Relevance 0
Our immunohistochemical results showed that SNCG predominantly expressed in cytoplasm of colon cancer cells, but rarely in adjacent normal epithelium, which are consistent with previous report [25].
Gene_expression (expressed) of SNCG in epithelium associated with colon cancer
5) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 0.68 Pain Relevance 0
Interestingly, in contrast to previous observations of an association between SNCG expression and tumor stage in many different cancers [11,15], levels of SNCG in colon adenocarcinoma tissues did not display any significant difference between stages I-II and III-IV [28.1% (32/114) and 36.5% (42/115), P = 0.172].
Gene_expression (expression) of SNCG in colon associated with cancer and colon cancer
6) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.52 Pain Relevance 0
Previous studies indicate that SNCG expression follows a stage specific in breast cancer.
Gene_expression (expression) of SNCG associated with breast cancer
7) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.90 Pain Relevance 0
We also found that SNCG was strongly expressed in colon neuron-chords, vascular endothelial cells, and smooth muscle cells of nearly all colon cancer specimens.
Gene_expression (expressed) of SNCG in endothelial cells associated with colon cancer
8) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.39 Pain Relevance 0
While only 4 SNCG-positive cases were detected in 194 tumor-adjacent normal tissues (2.1%), moderate or strong expression of SNCG protein was detectable in 74 of 229 colon cancer cases (32.3%).
Gene_expression (expression) of SNCG protein in colon associated with cancer and colon cancer
9) Confidence 0.78 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.60 Pain Relevance 0
As shown in Figure 1A, SNCG specifically expressed in the cytoplasm of cancer cells, whereas no expression observed in the adjacent normal epithelium.
Neg (no) Gene_expression (expressed) of SNCG in epithelium associated with cancer
10) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.29 Pain Relevance 0
SNCG was overexpressed in 35% (34/97) of adenocarcinoma tissues from patients with normal preoperative serum CEA level.
Gene_expression (overexpressed) of SNCG associated with adenocarcinoma
11) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 0.67 Pain Relevance 0
Expression of SNCG in primary tumors (P = 0.023) was also significantly associated with recurrence.
Gene_expression (Expression) of SNCG associated with cancer and recurrence
12) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 2.36 Pain Relevance 0
Previously, we demonstrated that expression of SNCG in breast cancer cells leads to a significant increase in motility and a profound augmentation of metastasis in tumor xenograft [12].
Gene_expression (expression) of SNCG associated with cancer, breast cancer and metastasis
13) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 2.07 Pain Relevance 0
Overall, there was no significant correlation between SNCG protein expression and age, tumor size, tumor differentiation, depth of invasion, TNM stage, and preoperative serum CEA levels.
Gene_expression (expression) of SNCG protein associated with cancer
14) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.61 Pain Relevance 0
SNCG overexpression correlates with poor outcome and is an independent prognostic indicator
Gene_expression (overexpression) of SNCG
15) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 2.19 Pain Relevance 0
However, expression of SNCG in colon adenocarcinoma tissues was strongly correlated with intravascular embolus (P = 0.025).
Gene_expression (expression) of SNCG in colon associated with embolism and colon cancer
16) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.46 Pain Relevance 0
Differences in SNCG protein expression between cancer and non-cancer tissues in the same patient were analyzed using a paired T test.
Spec (analyzed) Gene_expression (expression) of SNCG protein associated with cancer
17) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 0.47 Pain Relevance 0
To study whether SNCG is a prognostic factor for colon cancer, we correlated SNCG expression in tumors with a median follow-up of 44 ± 28 months (range 11 days to 121 months) after colon cancer surgery.
Gene_expression (expression) of SNCG in colon associated with cancer and colon cancer
18) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 2.00 Pain Relevance 0
While 71.4% of advanced breast cancers are positive for SNCG expression, only 26.8% of stage I/II breast cancers are positive for SNCG expression and 5.2% of benign hyperplasia expresses SNCG.
Gene_expression (expresses) of SNCG associated with breast cancer, advanced or metastatic breast cancer and hyperplasia
19) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 1.64 Pain Relevance 0
Studies in phylogenetically distant vertebrate species show that 3 functionally different endocytosis receptors are present in SEC: the COLLA-R, the MAN-R, and the HA/S-R.
Gene_expression (present) of S-R
20) Confidence 0.65 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0 Pain Relevance 0

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