INT23468

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Context Info
Confidence 0.76
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 8.04
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fbn1) proteinaceous extracellular matrix (Fbn1)
Anatomy Link Frequency
brain 1
extracellular matrix 1
TSK 1
body 1
Fbn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 5 90.72 High High
fibrosis 115 89.92 High High
cytokine 16 73.44 Quite High
Inflammation 14 73.04 Quite High
Thoracotomy 6 28.96 Quite Low
Enkephalin 1 25.00 Low Low
ketamine 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Marfan Syndrome 28 99.32 Very High Very High Very High
Systemic Sclerosis 60 99.04 Very High Very High Very High
Ectopia Lentis 6 98.64 Very High Very High Very High
Syndrome 145 97.72 Very High Very High Very High
Mixed Connective Tissue Disorder 7 97.68 Very High Very High Very High
Multiple System Atrophy 1 96.84 Very High Very High Very High
Targeted Disruption 11 93.28 High High
Disease 27 92.92 High High
Injury 53 90.80 High High
INFLAMMATION 19 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TSK mutation leads to the production and secretion of a larger mutant FBN-1 protein [14].
Gene_expression (production) of FBN-1 in TSK
1) Confidence 0.76 Published 2008 Journal Radiat Oncol Section Body Doc Link PMC2599892 Disease Relevance 1.03 Pain Relevance 0.19
It seems that an altered FBN-1/TGF-?
Gene_expression (/) of FBN-1
2) Confidence 0.66 Published 2008 Journal Radiat Oncol Section Body Doc Link PMC2599892 Disease Relevance 1.11 Pain Relevance 0.16
Abnormal expression of FBN-1 has also been noted in systemic sclerosis [18].
Gene_expression (expression) of FBN-1 associated with systemic sclerosis
3) Confidence 0.59 Published 2008 Journal Radiat Oncol Section Body Doc Link PMC2599892 Disease Relevance 1.14 Pain Relevance 0.17
A previous study [12] showed that fibrillin-1 and fibulin-2 were co-localized in the same tissues of the body, and it was suggested that fibrillin-1 assumes the functions of fibulin-2 if the physiological conditions permit.
Gene_expression (assumes) of fibrillin-1 in body
4) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1794134 Disease Relevance 0.11 Pain Relevance 0
At 3 days the top networks identified by IPA involve cell cycle progression (up-regulation of Foxm1, Cdc2, Cdc20, Ccnd1 and IL6 - Figure 4A), and activation of fibroblastic cells with production of extracellular matrix components (up-regulation of Igf1, Tnfrsf12A, Eln, Fbn1, Col3A1, Serpine1 and Thbs1 - Figure 4B).
Gene_expression (production) of Fbn1 in extracellular matrix
5) Confidence 0.44 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.48 Pain Relevance 0.24
The recent discovery of ADAMTS17 and ADAMTSL4 mutations in a WMS-like syndrome [24] and in recessive isolated ectopia lentis [25] respectively, further strengthen genetic associations between fibrillin-1 microfibrils and the ADAMTS superfamily.
Gene_expression (microfibrils) of fibrillin-1 associated with ectopia lentis and syndrome
6) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941456 Disease Relevance 1.56 Pain Relevance 0
Thus, several lines of genetic or experimental evidence suggest a functional link between members of the ADAMTS superfamily and fibrillin-1 microfibrils or fibrillin-1 binding proteins such as LTBP1.
Gene_expression (microfibrils) of fibrillin-1
7) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941456 Disease Relevance 1.29 Pain Relevance 0
Thus, several lines of genetic or experimental evidence suggest a functional link between members of the ADAMTS superfamily and fibrillin-1 microfibrils or fibrillin-1 binding proteins such as LTBP1.
Gene_expression (microfibrils) of fibrillin-1
8) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941456 Disease Relevance 1.23 Pain Relevance 0
By synthesizing several structurally related brain-gut-skin triangle peptides, a number of advantageous features of the thioanisole-mediated deprotecting procedure were demonstrated.
Gene_expression (synthesizing) of brain-gut-skin in brain
9) Confidence 0.00 Published 1985 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 2416704 Disease Relevance 0.10 Pain Relevance 0

General Comments

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