INT23469

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Context Info
Confidence 0.26
First Reported 1986
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.05
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (St8sia2)
St8sia2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 18 100.00 Very High Very High Very High
Action potential 1 94.60 High High
addiction 1 93.44 High High
sodium channel 11 81.28 Quite High
Disease Link Frequency Relevance Heat
Immunization 1 54.76 Quite High
Poisoning 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tetrodotoxin (TTX) quantitatively stabilizes the solubilized complex against both the loss of beta 1 and the loss of [3H]STX binding activity.
Negative_regulation (loss) of STX Binding (activity) of associated with tetrodotoxin
1) Confidence 0.26 Published 1986 Journal J. Biol. Chem. Section Abstract Doc Link 2416745 Disease Relevance 0 Pain Relevance 0.56
Treatment of the channel with 1.0 M MgCl2 followed by sedimentation through sucrose gradients results in complete separation of beta 1 from the alpha-beta 2 complex and complete loss of [3H]saxitoxin (STX) binding activity.
Negative_regulation (loss) of STX Binding (activity) of
2) Confidence 0.26 Published 1986 Journal J. Biol. Chem. Section Abstract Doc Link 2416745 Disease Relevance 0 Pain Relevance 0.44
The decrease in binding affinity for TTX and STX in low-affinity subtypes is due to a 3-9-fold decrease in the association rate constant and a 4-8-fold increase in the dissociation rate constant.
Negative_regulation (decrease) of STX Binding (affinity) of associated with tetrodotoxin
3) Confidence 0.22 Published 1987 Journal Biochemistry Section Abstract Doc Link 2447944 Disease Relevance 0 Pain Relevance 0.48
The S1A5 mAb, despite its ability to inhibit STX binding in vitro, was completely ineffectual in situ.
Negative_regulation (inhibit) of STX Binding (binding) of
4) Confidence 0.06 Published 1989 Journal J Toxicol Environ Health Section Abstract Doc Link 2547081 Disease Relevance 0.05 Pain Relevance 0.15

General Comments

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