INT23471

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Context Info
Confidence 0.24
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.39
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cpt1b) mitochondrion (Cpt1b) transferase activity, transferring acyl groups (Cpt1b)
lipid metabolic process (Cpt1b)
Anatomy Link Frequency
skin 1
ventricular system 1
Cpt1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 10 99.60 Very High Very High Very High
sodium channel 8 99.42 Very High Very High Very High
tetrodotoxin 12 98.32 Very High Very High Very High
cytokine 2 92.16 High High
Inflammatory response 4 84.40 Quite High
Dismenorea 2 82.84 Quite High
Arachnoiditis 2 79.68 Quite High
cva 6 75.24 Quite High
noradrenaline 2 65.88 Quite High
Potency 2 58.24 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 99.60 Very High Very High Very High
Hydrocephalus 72 91.52 High High
Dysmenorrhea 2 82.84 Quite High
Arachnoiditis 2 79.68 Quite High
Cv General 3 Under Development 6 75.24 Quite High
Fibrosis 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that association of the alpha and beta 1 subunits is required to maintain the STX/TTX binding site in a conformation with high affinity for STX and TTX in the detergent-solubilized state.
beta 1 Binding (association) of associated with tetrodotoxin
1) Confidence 0.24 Published 1986 Journal J. Biol. Chem. Section Abstract Doc Link 2416745 Disease Relevance 0 Pain Relevance 0.63
Role of the beta 1 and beta 2 subunits in saxitoxin binding.
beta 1 Binding (binding) of
2) Confidence 0.22 Published 1986 Journal J. Biol. Chem. Section Title Doc Link 2416745 Disease Relevance 0 Pain Relevance 0.46
They further show that the activity of compounds at these tissues can be used to assess their selectivity for beta 1- or beta 2-adrenoceptors in vivo.
beta 1 Binding (selectivity) of
3) Confidence 0.08 Published 1988 Journal J Pharmacol Methods Section Abstract Doc Link 2906105 Disease Relevance 0.14 Pain Relevance 0.28
Inflammation is known to affect beta-1 integrin-matrix interactions and induce the interstitial pressure lowering effects in skin [39,40].
beta-1 Binding (interactions) of in skin associated with inflammation
4) Confidence 0.03 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0.69 Pain Relevance 0.29
Modulation of beta-1 integrin-matrix interactions in the periventricular parenchyma reduces interstitial fluid pressure relative to that in the ventricular system.
beta-1 Binding (interactions) of in ventricular system
5) Confidence 0.03 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0.56 Pain Relevance 0.16

General Comments

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