INT234717

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 6.14
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1)
Anatomy Link Frequency
d cells 2
epithelial cells 2
liver 1
lung 1
neutrophil 1
Cxcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 42 100.00 Very High Very High Very High
cytokine 318 99.66 Very High Very High Very High
agonist 20 99.44 Very High Very High Very High
chemokine 101 96.88 Very High Very High Very High
Inflammation 340 92.80 High High
Inflammatory response 61 90.40 High High
COX-2 inhibitor 69 88.72 High High
tolerance 9 81.44 Quite High
Arthritis 37 74.32 Quite High
anesthesia 5 40.88 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 415 100.00 Very High Very High Very High
Herpes Simplex Virus 714 99.82 Very High Very High Very High
Infection 377 98.14 Very High Very High Very High
Keratitis 46 97.68 Very High Very High Very High
Apoptosis 32 95.16 Very High Very High Very High
Arthritis 53 94.80 High High
Acute-phase Reaction 2 80.80 Quite High
Reperfusion Injury 2 77.96 Quite High
Pressure And Volume Under Development 11 76.20 Quite High
Hypercalcemia 7 63.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
is the major cytokine responsible for regulation of MIP-2 and KC.
Regulation (regulation) of KC associated with cytokine
1) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 1.24 Pain Relevance 0.39
In addition, CXCL1, which promotes neutrophil recruitment, is also up-regulated by the MDL-1 agonist.
Regulation (regulated) of CXCL1 in neutrophil associated with agonist
2) Confidence 0.28 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.38 Pain Relevance 0.29
Consistent with the first experiment, there was a significant effect of mechanical ventilation on lung levels of KC/CXCL1, MCP1/CCL2, MIP1?
Regulation (effect) of CXCL1 in lung
3) Confidence 0.26 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.44 Pain Relevance 0.25
Epithelial cell IL-6, CXCL1 and CCL20 responses were evident following LPS treatment, compared with epithelial cells in control media, by 6 h (Fig. 6E–G) but an increase in PGE concentration in response to LPS was only detected at 30 h (Fig. 6H).


Regulation (responses) of CXCL1 in epithelial cells
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.22 Pain Relevance 0.14
mice, the concentrations of IL-6, CXCL1, CCL20 or PGE in supernatants did not differ significantly between control and LPS treated cells (Fig. 8A–D).
Regulation (concentrations) of CXCL1
5) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.14 Pain Relevance 0.07
The concentrations of the inflammatory mediators IL-6, CXCL1, CCL20 and PGE in the supernatant of stromal (Fig. 6I–L) or epithelial cells (Fig. 6M–P) did not differ significantly between control and LPS treated cells.
Regulation (concentrations) of CXCL1 in epithelial cells associated with inflammatory mediators
6) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.30 Pain Relevance 0.15
, but had no effect on concentration of IL-17 and CXCL1/KC (data not shown).
Spec (whether) Regulation (effect) of CXCL1
7) Confidence 0.15 Published 2010 Journal Respir Res Section Body Doc Link PMC2906448 Disease Relevance 0.74 Pain Relevance 0.38
The purpose of this study was to quantify the effects of liver transplantation on KC immunomodulatory function, focusing specifically on Fas ligand (FasL) expression and their role in allo-reactive T cell apoptosis in chronic accepted and acutely rejected hepatic allografts.


Regulation (effects) of KC in liver associated with apoptosis
8) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.27 Pain Relevance 0.10
Compared to uninfected HMVEC-d cells, KSHV infection triggered an appreciable (1.5-2) fold induction in the secretion of pro-ICs, such as growth regulated oncogene (GRO), GRO?
Regulation (regulated) of GRO in d cells associated with herpes simplex virus, infection and cytokine
9) Confidence 0.00 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.81 Pain Relevance 0.43
Compared to uninfected HMVEC-d cells, KSHV infection triggered an appreciable (1.5-2) fold induction in the secretion of pro-ICs, such as growth regulated oncogene (GRO), GRO?
Regulation (regulated) of GRO in d cells associated with herpes simplex virus, infection and cytokine
10) Confidence 0.00 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.81 Pain Relevance 0.43
In pattern four, the expression of KSHV induced GRO, RANTES and SDF-1 genes were not significantly affected by NS-398 and si-COX-2 at 4 h PI, while significant reductions were observed at 8 and 24 h PI (Figures S6C, S6D, and 5D).
Regulation (affected) of GRO associated with herpes simplex virus
11) Confidence 0.00 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.79 Pain Relevance 0.29

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