INT23472

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Context Info
Confidence 0.42
First Reported 1985
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 18
Total Number 20
Disease Relevance 1.73
Pain Relevance 7.74

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Golgi apparatus (St8sia2)
Anatomy Link Frequency
brain 2
neurons 1
hindlimb muscle 1
myotubes 1
St8sia2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 67 100.00 Very High Very High Very High
sodium channel 38 99.98 Very High Very High Very High
Glutamate 3 99.16 Very High Very High Very High
Action potential 13 95.12 Very High Very High Very High
addiction 2 92.64 High High
ischemia 162 92.16 High High
Hippocampus 27 88.20 High High
agonist 39 86.80 High High
Neuronal excitability 15 76.08 Quite High
antagonist 3 73.64 Quite High
Disease Link Frequency Relevance Heat
Shellfish Poisoning 4 94.48 High High
Cv Unclassified Under Development 156 92.16 High High
Immunization 6 88.92 High High
Cv General 4 Under Development 3 87.44 High High
Stress 3 84.84 Quite High
Reprotox - General 1 12 84.24 Quite High
Feminization 3 76.96 Quite High
Injury 9 70.72 Quite High
Aging 12 58.48 Quite High
Targeted Disruption 3 56.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The sodium channel interacts with TTX and STX with higher affinity at depolarized potentials, so these two residues must make a greater contribution to toxin binding in the low affinity state.
STX Binding (interacts) of associated with tetrodotoxin and sodium channel
1) Confidence 0.42 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8386312 Disease Relevance 0 Pain Relevance 0.90
We report here the detection of Na channels with low-affinity binding of STX and TTX, accounting for 50-60% of the Na channels in rat hindlimb muscle 4-5 days after denervation.
STX Binding (binding) of in hindlimb muscle associated with tetrodotoxin
2) Confidence 0.34 Published 1985 Journal Brain Res. Section Abstract Doc Link 2579711 Disease Relevance 0 Pain Relevance 0.61
This indicates that association of the alpha and beta 1 subunits is required to maintain the STX/TTX binding site in a conformation with high affinity for STX and TTX in the detergent-solubilized state.
STX Binding (affinity) of associated with tetrodotoxin
3) Confidence 0.33 Published 1986 Journal J. Biol. Chem. Section Abstract Doc Link 2416745 Disease Relevance 0 Pain Relevance 0.68
With this assay the amount of STX and tetrodotoxin needed to displace 50% of bound [3H]STX was 1.7 and 1.76 ng/ml for buffer samples, respectively.
STX Binding (bound) of associated with tetrodotoxin
4) Confidence 0.31 Published 1993 Journal Anal. Biochem. Section Abstract Doc Link 8391763 Disease Relevance 0.36 Pain Relevance 0.19
STX, a diphenylacrylamide compound (SERM) that does not bind ER-?
STX Neg (not) Binding (bind) of
5) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799530 Disease Relevance 0.49 Pain Relevance 0.32
STX does not bind to or activate the classical nuclear ERs [42], [43] and was recently shown to activate the MAPK and PI3K pathways in endometrial cells [42].
STX Neg (not) Binding (bind) of
6) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799530 Disease Relevance 0.35 Pain Relevance 0.10
The decrease in binding affinity for TTX and STX in low-affinity subtypes is due to a 3-9-fold decrease in the association rate constant and a 4-8-fold increase in the dissociation rate constant.
STX Binding (affinity) of associated with tetrodotoxin
7) Confidence 0.25 Published 1987 Journal Biochemistry Section Abstract Doc Link 2447944 Disease Relevance 0 Pain Relevance 0.48
Treatment of the channel with 1.0 M MgCl2 followed by sedimentation through sucrose gradients results in complete separation of beta 1 from the alpha-beta 2 complex and complete loss of [3H]saxitoxin (STX) binding activity.
STX Binding (activity) of
8) Confidence 0.21 Published 1986 Journal J. Biol. Chem. Section Abstract Doc Link 2416745 Disease Relevance 0 Pain Relevance 0.44
There is little or no correlation between the amount of beta 2 in the sodium channel complex and the ability of the preparation to bind [3H]STX.
STX Binding (bind) of associated with sodium channel
9) Confidence 0.21 Published 1986 Journal J. Biol. Chem. Section Abstract Doc Link 2416745 Disease Relevance 0 Pain Relevance 0.68
Tetrodotoxin (TTX) quantitatively stabilizes the solubilized complex against both the loss of beta 1 and the loss of [3H]STX binding activity.
STX Binding (activity) of associated with tetrodotoxin
10) Confidence 0.21 Published 1986 Journal J. Biol. Chem. Section Abstract Doc Link 2416745 Disease Relevance 0 Pain Relevance 0.56
Because STX modulation of inwardly rectifying potassium currents in hypothalamic neurons is not impaired in GPR30 null mice [10], G1 and STX might exert their neuroprotective effects through the activation of two distinct G protein-coupled receptors, the one binding STX remaining to be identified.
STX Binding (binding) of in neurons
11) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799530 Disease Relevance 0.08 Pain Relevance 0.18
The subtypes studied include Na channels from rat skeletal muscle and rat brain, which have high affinity for TTX/STX, and Na channels from denervated rat skeletal muscle and canine heart, which have about 20-60-fold lower affinity for these toxins at 22 degrees C.
STX Binding (affinity) of in brain associated with tetrodotoxin
12) Confidence 0.18 Published 1987 Journal Biochemistry Section Abstract Doc Link 2447944 Disease Relevance 0 Pain Relevance 0.49
Scatchard analysis showed the channels in TH-treated myotubes to have lower affinity for STX than those in control cells.
STX Binding (affinity) of in myotubes
13) Confidence 0.15 Published 1989 Journal Endocrinology Section Abstract Doc Link 2546750 Disease Relevance 0 Pain Relevance 0.52
Expression of Na channels was determined by measurements of the binding of [3H]saxitoxin (STX).
STX Binding (binding) of
14) Confidence 0.11 Published 1989 Journal Endocrinology Section Abstract Doc Link 2546750 Disease Relevance 0 Pain Relevance 0.54
The S1A5 mAb, despite its ability to inhibit STX binding in vitro, was completely ineffectual in situ.
STX Binding (binding) of
15) Confidence 0.06 Published 1989 Journal J Toxicol Environ Health Section Abstract Doc Link 2547081 Disease Relevance 0.05 Pain Relevance 0.15
These hybrids, termed S1A5 and S3E.2, secreted specific anti-STX antibodies that did not recognize the closely related toxin tetrodotoxin (TDT), as determined by competition ELISA.
STX Neg (not) Binding (recognize) of associated with tetrodotoxin
16) Confidence 0.06 Published 1989 Journal J Toxicol Environ Health Section Abstract Doc Link 2547081 Disease Relevance 0.09 Pain Relevance 0.18
The sodium channel blocker saxitoxin (STX) was conjugated to keyhole limpet hemocyanin (KLH) and used to immunize BALB/c mice.
STX Binding (conjugated) of associated with sodium channel
17) Confidence 0.05 Published 1989 Journal J Toxicol Environ Health Section Abstract Doc Link 2547081 Disease Relevance 0.08 Pain Relevance 0.14
The protective ability of these antibodies was tested by a competitive displacement assay for [3H]STX binding on rat brain membranes.
STX Binding (binding) of in brain
18) Confidence 0.05 Published 1989 Journal J Toxicol Environ Health Section Abstract Doc Link 2547081 Disease Relevance 0.07 Pain Relevance 0.19
Purified S3E.2 strongly displaced [3H]STX binding, whereas S1A5 weakly inhibited [3H]STX binding to membranes.
STX Binding (binding) of
19) Confidence 0.05 Published 1989 Journal J Toxicol Environ Health Section Abstract Doc Link 2547081 Disease Relevance 0.07 Pain Relevance 0.19
Purified S3E.2 strongly displaced [3H]STX binding, whereas S1A5 weakly inhibited [3H]STX binding to membranes.
STX Binding (binding) of
20) Confidence 0.05 Published 1989 Journal J Toxicol Environ Health Section Abstract Doc Link 2547081 Disease Relevance 0.07 Pain Relevance 0.19

General Comments

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