INT23480

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Context Info
Confidence 0.39
First Reported 1985
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 3.51
Pain Relevance 4.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PPAP2A) plasma membrane (PPAP2A) lipid metabolic process (PPAP2A)
Anatomy Link Frequency
blood 2
plasma 1
outflow 1
thyroid 1
cerebrospinal fluid 1
PPAP2A (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 18 100.00 Very High Very High Very High
noradrenaline 3 100.00 Very High Very High Very High
Clonidine 59 99.72 Very High Very High Very High
Catecholamine 10 98.32 Very High Very High Very High
Neuropeptide 2 94.00 High High
cINOD 2 88.92 High High
antagonist 1 79.44 Quite High
adenocard 6 72.96 Quite High
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Obesity 42 100.00 Very High Very High Very High
Thyroid Disease 10 99.46 Very High Very High Very High
Hypotension 2 89.88 High High
INFLAMMATION 2 88.68 High High
Congenital Anomalies 1 88.20 High High
Hypogonadotropic Hypogonadism 6 83.28 Quite High
Lumbar Puncture Related Headaches 4 81.36 Quite High
Starvation 5 80.88 Quite High
Heart Rate Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The regulation of alpha-2 adrenoceptors and alpha-2 adrenergic responses by alpha-2 agonist treatment was investigated in in vitro and in vivo conditions.
Regulation (regulation) of alpha-2 associated with agonist
1) Confidence 0.39 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2987483 Disease Relevance 0.36 Pain Relevance 0.40
We show that the LPS-induced up-regulation of COX-2 depends on the activity of the Mg(+2)-dependent phosphatidic acid phosphohydrolase 1 (PAP-1).
Regulation (depends) of PAP-1
2) Confidence 0.37 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16950767 Disease Relevance 0.09 Pain Relevance 0.09
Direct intraneural recordings using microneurography of postganglionic sympathetic nerve activity in humans permit assessment of effects of alpha-2 agonists on central sympathetic outflow.
Regulation (effects) of alpha-2 in outflow associated with agonist
3) Confidence 0.35 Published 1985 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2417051 Disease Relevance 0 Pain Relevance 0.26
The regulation of alpha-2 adrenoceptors and alpha-2 adrenergic responses by alpha-2 agonist treatment was investigated in in vitro and in vivo conditions.
Regulation (regulation) of alpha-2 associated with agonist
4) Confidence 0.34 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2987483 Disease Relevance 0.37 Pain Relevance 0.41
We show that the LPS-induced up-regulation of COX-2 depends on the activity of the Mg(+2)-dependent phosphatidic acid phosphohydrolase 1 (PAP-1).
Regulation (depends) of phosphatidic acid phosphohydrolase 1
5) Confidence 0.32 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16950767 Disease Relevance 0.09 Pain Relevance 0.09
Microneurographic studies during administration of clonidine suggest that alpha-2 agonists produce a dose-related modulation of central sympathetic nerve discharge, but that other mechanisms presumably involving stimulation of inhibitory peripheral presynaptic alpha-2 receptors are also involved in the antihypertensive action of these agents.
Regulation (modulation) of alpha-2 in sympathetic associated with agonist and clonidine
6) Confidence 0.30 Published 1985 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2417051 Disease Relevance 0 Pain Relevance 0.28
On the other hand, in hypothyroidism, there was no evidence of changes in either the alpha 2- or the beta-adrenoceptors.
Regulation (changes) of alpha 2 associated with thyroid disease
7) Confidence 0.23 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3734033 Disease Relevance 0.83 Pain Relevance 0.23
The effects of adrenaline, noradrenaline, and of the alpha 2- and beta-selective agonists clonidine and isoproterenol were studied in fifteen obese subjects before and after 4 weeks of caloric restriction (300 cal day-1).
Regulation (effects) of alpha 2 associated with obesity, agonist, noradrenaline and clonidine
8) Confidence 0.11 Published 1985 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 2859198 Disease Relevance 0.54 Pain Relevance 0.27
It is concluded that the inhibitory alpha 2-receptor pathway functions normally in all groups, indicating that the alpha 2-receptors and the alpha 2-receptor-mediated pathway in human adipocytes are relatively unaffected by thyroid hormones.
Neg (unaffected) Regulation (unaffected) of alpha 2 in thyroid associated with obesity
9) Confidence 0.05 Published 1987 Journal Metab. Clin. Exp. Section Abstract Doc Link 2823049 Disease Relevance 0.69 Pain Relevance 0.31
Alpha-2 adrenergic transmission and human baroreflex regulation.
Regulation (regulation) of Alpha-2
10) Confidence 0.04 Published 2004 Journal Hypertension Section Title Doc Link 15037555 Disease Relevance 0 Pain Relevance 0.28
To evaluate the alpha 2-noradrenergic regulation of arginine vasopressin (AVP) and oxytocin (OT) in normal humans, we measured the effect of the alpha 2-agonist clonidine on concentrations of these neuropeptides in both plasma and cerebrospinal fluid (CSF).
Regulation (regulation) of alpha 2-noradrenergic in plasma associated with neuropeptide, agonist and clonidine
11) Confidence 0.04 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 3431654 Disease Relevance 0.15 Pain Relevance 0.40
To evaluate the alpha 2-noradrenergic regulation of arginine vasopressin (AVP) and oxytocin (OT) in normal humans, we measured the effect of the alpha 2-agonist clonidine on concentrations of these neuropeptides in both plasma and cerebrospinal fluid (CSF).
Regulation (regulation) of alpha 2-noradrenergic in cerebrospinal fluid associated with neuropeptide, agonist and clonidine
12) Confidence 0.01 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 3431654 Disease Relevance 0.15 Pain Relevance 0.40
Our present findings demonstrate that, differently from in animal, in man testosterone has no role in modulating the effects of alpha-2 adrenergic activation by clonidine on blood pressure, catecholamine and GH release.
Regulation (effects) of alpha-2 in blood associated with catecholamine and clonidine
13) Confidence 0.01 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8905472 Disease Relevance 0 Pain Relevance 0.26
Thus, these data point to main role of the gonadal steroid testosterone in modulating the effects of alpha-2 adrenergic activation on blood pressure, catecholamine and GH release in animal.
Regulation (effects) of alpha-2 in blood associated with catecholamine
14) Confidence 0.01 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8905472 Disease Relevance 0.24 Pain Relevance 0.45

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