INT234810

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.64
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (RAB5A) plasma membrane (RAB5A) GTPase activity (RAB5A)
Anatomy Link Frequency
thyroid 1
tail 1
RAB5A (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 106 84.40 Quite High
Dopamine 1 78.88 Quite High
imagery 11 72.68 Quite High
Neurotransmitter 1 11.52 Low Low
Pain 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
dopamine receptor 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
lancinating pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 168 98.60 Very High Very High Very High
Adenoma 1 97.84 Very High Very High Very High
Diabetes Mellitus 4 96.40 Very High Very High Very High
Syndrome 21 93.60 High High
Diabetes Insipidus 1 92.32 High High
Repression 1 87.56 High High
Viral Meningitis 6 76.44 Quite High
Diarrhoea 2 75.04 Quite High
Insulin Resistance 1 65.44 Quite High
Dengue 22 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
307 suggests that while the C-tail is not essential for Rab5a interaction, it appears to have a role in regulating further trafficking of the hIP from the Rab5-early endosomes, perhaps to other Rab-containing transport vesicles, preventing it from recycling to the plasma membrane in a dysregulated manner.
Regulation (regulating) of Rab5 in tail
1) Confidence 0.38 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.16
Rab5 is required and directly controls the formation of early endosomes [40].
Regulation (controls) of Rab5
2) Confidence 0.30 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.46 Pain Relevance 0
Our primary siRNA screen has also indicated that targeting of the endocytic trafficking proteins and associated kinases, Rab5A, Rab7, Rab11b, ELKS, early endosome antigen 1 and MAPK8IP2, each resulted in significant decreases in DENV infection (Figure 2 and Additional File 2).
Regulation (targeting) of Rab5A associated with infection
3) Confidence 0.30 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.51 Pain Relevance 0
The control of thyroid hormone production depends on endocytic catalysts and the tandem regulators Rab5a and Rab7, which have been found in excess in thyroid adenomas [8].


Regulation (regulators) of Rab5a in thyroid associated with adenoma
4) Confidence 0.17 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0.67 Pain Relevance 0

General Comments

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