INT234814

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.33
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AGFG1) transport (AGFG1) Golgi apparatus (AGFG1)
RNA binding (AGFG1) cytoplasmic membrane-bounded vesicle (AGFG1) nucleus (AGFG1)
AGFG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 5 71.68 Quite High
Pain 8 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
lancinating pain 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
peripheral neuropathy 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Congenital analgesia 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 131 87.20 High High
Diabetes Mellitus 20 83.64 Quite High
Communicable Diseases 5 82.84 Quite High
Syndrome 107 76.36 Quite High
Mouth Disease 22 74.52 Quite High
Charcot Marie Tooth Disease 46 73.96 Quite High
Intellectual Impairment 21 73.36 Quite High
Choroideremia 16 65.44 Quite High
Pigment Disorder 10 63.48 Quite High
Targeted Disruption 6 43.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rab proteins are activated by guanine nucleotide exchange factors (RabGEFs) and deactivated by GTPase activating proteins (RabGAPs), which accelerate the slow intrinsic rates of nucleotide exchange and GTP hydrolysis.
Positive_regulation (activated) of Rab
1) Confidence 0.10 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0 Pain Relevance 0
Rab proteins are activated by guanine nucleotide exchange factors (RabGEFs) and deactivated by GTPase activating proteins (RabGAPs), which accelerate the slow intrinsic rates of nucleotide exchange and GTP hydrolysis.
Positive_regulation (activated) of RabGEFs
2) Confidence 0.10 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0 Pain Relevance 0
More than 60 human Rab proteins have been identified, and their function has been shown to depend on their interaction with different Rab-associated proteins regulating Rab activation, post-translational modification and intracellular localization.
Positive_regulation (activation) of Rab
3) Confidence 0.09 Published 2008 Journal Eur J Pediatr Section Abstract Doc Link PMC2413085 Disease Relevance 0.30 Pain Relevance 0
This means that isoprenylation can be influenced by drugs such as statins, which inhibit isoprenylation, or biphosphonates, which inhibit that farnesyl pyrophosphate synthase necessary for Rab GTPase activity.
Positive_regulation (necessary) of Rab
4) Confidence 0.09 Published 2008 Journal Eur J Pediatr Section Abstract Doc Link PMC2413085 Disease Relevance 1.41 Pain Relevance 0.07
More than 60 human Rab proteins have been identified, and their function has been shown to depend on their interaction with different Rab-associated proteins regulating Rab activation, post-translational modification and intracellular localization.
Positive_regulation (activation) of Rab
5) Confidence 0.09 Published 2008 Journal Eur J Pediatr Section Abstract Doc Link PMC2413085 Disease Relevance 0.30 Pain Relevance 0
Normally, GDP is tightly bound by Rab GTPases, and the low intrinsic rate of GDP dissociation makes GDP release the rate-limiting step of nucleotide exchange and Rab activation.
Positive_regulation (activation) of Rab
6) Confidence 0.05 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.31 Pain Relevance 0

General Comments

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