INT234822

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.76
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
fibroblasts 1
epithelium 1
CHML (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 7 27.52 Quite Low
Pain 1 8.80 Low Low
imagery 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
lancinating pain 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Choroideremia 169 98.64 Very High Very High Very High
Disease 21 97.68 Very High Very High Very High
Blindness 2 95.44 Very High Very High Very High
Hepatitis C Virus Infection 3 84.48 Quite High
Hepatitis 1 75.04 Quite High
Death 2 72.16 Quite High
Toxicity 3 69.64 Quite High
Stress 5 69.12 Quite High
Salmonella Infection 1 50.88 Quite High
Intellectual Impairment 4 47.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the other isoform, REP-2, seems to be sufficient for the geranylgeranylation of all Rab GTPases in all tissues, the retinal pigment epithelium seems to be the exception.
Positive_regulation (sufficient) of REP-2 in epithelium
1) Confidence 0.06 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0.83 Pain Relevance 0
Surprisingly, we did not see a compensatory increase in the protein and RNA levels of REP-2 in fibroblasts or monocytes from CHM patients.
Positive_regulation (increase) of REP-2 in fibroblasts associated with choroideremia
2) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.93 Pain Relevance 0

General Comments

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