INT234827

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 12
Disease Relevance 0.54
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (RAB5A) plasma membrane (RAB5A) GTPase activity (RAB5A)
Anatomy Link Frequency
upper 2
plasma 1
RAB5A (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1060 99.62 Very High Very High Very High
cytokine 2 75.64 Quite High
imagery 70 5.00 Very Low Very Low Very Low
dopamine receptor 10 5.00 Very Low Very Low Very Low
cINOD 10 5.00 Very Low Very Low Very Low
ischemia 10 5.00 Very Low Very Low Very Low
Dopamine 10 5.00 Very Low Very Low Very Low
lancinating pain 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Salmonella Infection 2 99.50 Very High Very High Very High
Hepatitis 2 67.44 Quite High
Hepatitis C Virus Infection 6 65.92 Quite High
Viral Infection 2 52.92 Quite High
Choroideremia 6 40.80 Quite Low
Death 2 40.28 Quite Low
Disease 32 38.48 Quite Low
Hemophagocytic Lymphohistiocytosis 4 29.48 Quite Low
Blindness 2 26.64 Quite Low
Syndrome 42 26.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In light of the latter evidence that endogenous Rab5 may be activated in response to cicaprost stimulation, we next sought to examine the agonist-induced co-localization of endogenous Rab5 with the hIP.
Positive_regulation (activated) of Rab5 associated with agonist
1) Confidence 0.59 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.05
It was also notable that the time-dependent activation/translocation of Rab5 from the S100 fraction almost paralleled that observed in the ELISA-based internalizations and the immunolocalizations whereby the activation of Rab5 in response to hIP signaling was both rapid (~ 30 min) and transient (~ 3 h).
Positive_regulation (activation) of Rab5
2) Confidence 0.59 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.18
Furthermore, following cicaprost stimulation, there was an increase in the amount of both GFP-Rab5a and endogenous Rab5 associated with the hIP immunoprecipitates (Fig. 5; upper panel).
Positive_regulation (increase) of GFP-Rab5a in upper
3) Confidence 0.59 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.22
These data suggest that agonist-dependent activation of the hIP leads to direct time-dependent activation of Rab5 leading to its net translocation from the cytosolic/soluble fraction leading to its activation.
Positive_regulation (activation) of Rab5 associated with agonist
4) Confidence 0.59 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.29
hIP-mediated activation of Rab5
Positive_regulation (activation) of Rab5
5) Confidence 0.43 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.03
Furthermore, stimulation of cells with cicaprost led to a significant increase in the size of the Rab5aQ79L-positive endosomal structures (Fig. 2C, GFP).
Positive_regulation (increase) of Rab5aQ79L
6) Confidence 0.43 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.11
The increase in immunoprecipitation of Rab5a in response to agonist was not due to an increase in hIP or Rab5a expression levels (data not shown and Fig. 5; lower panel) or in the level of the hIP present in the anti-HA immunoprecipitates per se (Fig. 5; middle panel) and, hence, was due to enhanced interaction between hIP and Rab5a.
Positive_regulation (increase) of Rab5a associated with agonist
7) Confidence 0.43 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.25
Furthermore, following cicaprost stimulation, there was an increase in the amount of both GFP-Rab5a and endogenous Rab5 associated with the hIP immunoprecipitates (Fig. 5; upper panel).
Positive_regulation (increase) of Rab5 in upper
8) Confidence 0.43 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.22
Even at 30 min post-agonist stimulation, there was evidence that the hIP and Rab5a co-localized to the cell surface and to vesicles just inside the cell membrane (Fig. 3, 0.5 h; indicated by the arrows) while at 1 h–2 h post-stimulation, there was almost complete loss of cell surface receptors and increased association with Rab5a-positive endosomes of increased size and proximity from the plasma membrane (Fig. 3, 1 h; Anti-HA).
Positive_regulation (increased) of Rab5a in plasma associated with agonist
9) Confidence 0.40 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.12
Co-immunoprecipitation studies confirmed a direct physical interaction between the hIP and Rab5a that was augmented by cicaprost.
Positive_regulation (augmented) of Rab5a
10) Confidence 0.40 Published 2008 Journal Biochim Biophys Acta Section Abstract Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.15
SopE has GEF activity for Rab5a, stimulating activated GTP-bound Rab5a and preventing its membrane extraction by RabGDI.
Positive_regulation (activated) of Rab5a
11) Confidence 0.18 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0.28 Pain Relevance 0.04
In Salmonella infections, there is evidence that Rab5a is stabilized on the phagosome by the Salmonella type III secretory protein SopE [23].
Positive_regulation (stabilized) of Rab5a associated with salmonella infection
12) Confidence 0.18 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0.26 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox