INT234828

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.05
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion organization (RAB3A) plasma membrane (RAB3A) GTPase activity (RAB3A)
protein complex (RAB3A) cytoplasm (RAB3A)
Anatomy Link Frequency
brain 1
RAB3A (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 1 96.28 Very High Very High Very High
cytokine 4 89.04 High High
Inflammation 35 88.64 High High
agonist 26 81.96 Quite High
lancinating pain 1 79.28 Quite High
peripheral neuropathy 1 64.04 Quite High
Arthritis 5 50.72 Quite High
Pain 1 47.28 Quite Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 16 99.64 Very High Very High Very High
Cancer 20 97.80 Very High Very High Very High
INFLAMMATION 42 88.64 High High
Syndrome 21 88.24 High High
Hereditary Sensory And Autonomic Neuropathies 5 81.56 Quite High
Pain 2 79.28 Quite High
Mouth Disease 4 73.00 Quite High
Charcot Marie Tooth Disease 8 72.44 Quite High
Ulcers 1 68.84 Quite High
Microphthalmia 1 65.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rab3A is the most abundantly expressed protein in the brain, where it is present in all synapses and involved in calcium-dependent neurotransmitter release [13].
Gene_expression (expressed) of Rab3A in brain associated with neurotransmitter
1) Confidence 0.30 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 1.61 Pain Relevance 0.16
Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4) known to be important in cancer.
Gene_expression (expression) of RAB3A associated with cancer
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2970545 Disease Relevance 0.45 Pain Relevance 0.21

General Comments

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