INT234855

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.65
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dsp) structural molecule activity (Dsp) cytoskeleton (Dsp)
protein binding, bridging (Dsp) cytoplasm (Dsp)
Anatomy Link Frequency
plaque 1
cleavage 1
corneal epithelium 1
Dsp (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 78 99.66 Very High Very High Very High
addiction 12 94.00 High High
metalloproteinase 36 5.00 Very Low Very Low Very Low
agonist 30 5.00 Very Low Very Low Very Low
corticosteroid 12 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 306 96.84 Very High Very High Very High
Bullous Skin Disease 1824 91.84 High High
Acantholysis 390 91.04 High High
Salivary Gland Disease 6 87.68 High High
Non-genital Cutaneous Warts 6 58.80 Quite High
Disease 108 44.68 Quite Low
Alopecia 12 30.96 Quite Low
Autoimmune Disease 24 22.28 Low Low
Heart Defects 24 16.20 Low Low
Death 6 15.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it is unclear at present which desmosomal cadherin isoforms are capable to heretophilically bind to each other and thus interpretation of these distribution patterns with respect to their relevance for mechanical adhesion is preliminary.
Localization (interpretation) of desmosomal cadherin associated with adhesions
1) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.10 Pain Relevance 0
Proteolytic cleavage of desmosomal cadherins
Localization (cleavage) of desmosomal in cleavage
2) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.07 Pain Relevance 0
The Ca2+-dependency of desmosomal cadherin-mediated binding
Localization (dependency) of desmosomal cadherin
3) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0 Pain Relevance 0
In addition to their localization within the desmosomal plaque, plakophilin 1 and 2 are also present inside nucleus and plakophilin 2 has been found to be part of the polymerase III complex which is responsible for generation of tRNA and rRNA (Mertens et al. 2001).
Localization (localization) of desmosomal in plaque
4) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.08 Pain Relevance 0
Interestingly, in the stratified corneal epithelium, only Dsg 1 and Dsc1 are present indicating that these desmosomal cadherins in the absence of Dsg 1 and Dsg 3 are sufficient to maintain cohesion in stratified epithelia also.
Neg (absence) Localization (absence) of desmosomal in corneal epithelium
5) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.09 Pain Relevance 0
Activation of PKC is required for translocation of desmosomal components to the cell membrane and for desmosome assembly (Sheu et al. 1989), but also was found to reduce desmosomal adhesion and to increase Ca2+-dependence of desmosomes (Kimura et al. 2007) indicating that regulation of desmosomal adhesion by PKC is complex.
Localization (translocation) of desmosomal associated with addiction, kinase c and adhesions
6) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.32 Pain Relevance 0.22

General Comments

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