INT234857

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 42
Total Number 45
Disease Relevance 27.75
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg3) plasma membrane (Dsg3)
Anatomy Link Frequency
epidermis 16
keratinocyte 4
cleavage 3
epithelium 2
adult epidermis 2
Dsg3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 429 85.40 High High
addiction 66 34.68 Quite Low
metalloproteinase 198 5.00 Very Low Very Low Very Low
agonist 165 5.00 Very Low Very Low Very Low
corticosteroid 70 5.00 Very Low Very Low Very Low
Pain 41 5.00 Very Low Very Low Very Low
imagery 37 5.00 Very Low Very Low Very Low
Inflammatory mediators 33 5.00 Very Low Very Low Very Low
antagonist 33 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 1847 100.00 Very High Very High Very High
Bullous Skin Disease 10584 99.84 Very High Very High Very High
Acantholysis 2217 99.68 Very High Very High Very High
Alopecia 154 99.64 Very High Very High Very High
Autoimmune Disease 172 98.84 Very High Very High Very High
Disease 762 98.72 Very High Very High Very High
Targeted Disruption 196 98.68 Very High Very High Very High
Blister 572 98.60 Very High Very High Very High
Carcinoma 33 98.60 Very High Very High Very High
Skin Diseases 185 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on this idea, one would predict that DSG3 is the predominant or the only DSG isoform expressed in the area where acantholysis occurs (e.g., in the deep layers of the oral mucosa).
Gene_expression (expressed) of DSG3 in oral mucosa associated with acantholysis
1) Confidence 0.78 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.45 Pain Relevance 0
A histological examination of other mouse tissues that express DSG3, such as the esophagus, the forestomach (which is lined by a stratified epithelium structurally similar to the epidermis), and the thymus, did not reveal abnormalities.
Gene_expression (express) of DSG3 in epidermis associated with congenital anomalies
2) Confidence 0.78 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.83 Pain Relevance 0
A likely explanation for the absence of lesions in these tissues lies in the expression of functionally redundant desmoglein isoforms which compensate for the loss of DSG3.
Gene_expression (expression) of desmoglein
3) Confidence 0.78 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.61 Pain Relevance 0
Based on this idea, one would predict that DSG3 is the predominant or the only DSG isoform expressed in the area where acantholysis occurs (e.g., in the deep layers of the oral mucosa).
Gene_expression (expressed) of DSG in oral mucosa associated with acantholysis
4) Confidence 0.68 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.44 Pain Relevance 0
Unlike the lesions observed in Dsg3-null mutants (Figures 2(c) and 2(d)), lesions in the Dsc3 null mice were restricted to the skin and were not present in internal stratified epithelia, such as those of the oral cavity.
Gene_expression (mutants) of Dsg3-null in skin
5) Confidence 0.68 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.79 Pain Relevance 0
Interestingly, both desmosomal cadherins are required to anchor hair follicles in the skin, as demonstrated by the cyclic hair loss observed both in Dsg3 null and Dsc3 null mice (Figure 3).
Gene_expression (null) of Dsg3 in hair associated with alopecia
6) Confidence 0.68 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.74 Pain Relevance 0
However, due to the synchronization of the mouse hair cycle (which does not occur in humans), this effect is much more severe in desmoglein and desmocollin null mice than in humans with the autoimmune disease.

5.

Gene_expression (synchronization) of desmoglein in hair associated with autoimmune disease
7) Confidence 0.68 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 1.21 Pain Relevance 0
In the skin of mice, DSG3 is restricted to the basal and immediate suprabasal cell layers, whereas DSG1 and 2 are present throughout the epithelium.
Gene_expression (present) of DSG3 in epithelium
8) Confidence 0.59 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.43 Pain Relevance 0
Because Dsg 3 is expressed throughout the spinous layers (Fig. 5), the expression patterns of Dsg 1 and Dsg 3 largely overlap in human adult epidermis (Mahoney et al. 2006; Spindler et al. 2007).
Gene_expression (expression) of Dsg 3 in adult epidermis
9) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.05 Pain Relevance 0
Dsg 3 is expressed in the basal layer as well as throughout the spinous layer indicating that in human epidermis the expression patterns of these two proteins broadly overlap.
Gene_expression (expressed) of Dsg 3 in epidermis
10) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.05 Pain Relevance 0
In multilayered squamous epithelium of mucous membranes, for instance of the oral cavity, Dsg 1 and Dsg 3 are strongly expressed throughout all layers, whereas Dsg 4 shows strong expression in superficial layers but is missing in the basal layer (Mahoney et al. 2006).
Gene_expression (expressed) of Dsg 3 in basal layer
11) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.10 Pain Relevance 0
For instance, Dsg 1 and Pkp 1 are most prominent in the superficial layers, whereas expression of Dsg 3 and Dsc 3 is strongest in the deep epidermis.
Gene_expression (expression) of Dsg 3 in epidermis
12) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.07 Pain Relevance 0
It was shown that forced overexpression of Dsg 3 in the suprabasal epidermis led to abnormal differentiation and hyperproliferation as well as perinatal lethality due to transepidermal water loss (Elias et al. 2001; Merritt et al. 2002).
Gene_expression (overexpression) of Dsg 3 in epidermis
13) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.08 Pain Relevance 0
Both Dsg 1 and Dsg 3 are expressed in the basal layer underneath the blister as well as in keratinocytes in the blister roof.
Gene_expression (expressed) of Dsg 3 in keratinocytes associated with blister
14) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.88 Pain Relevance 0
Based on the different autoantibody profiles in PV and PF together with the findings that Dsg 3 is present in the deep epidermis only whereas Dsg 1 is primarily expressed in the superficial epidermis, the desmoglein compensation hypothesis has been proposed to explain the epidermal cleavage planes typical for PV and PF.
Gene_expression (present) of Dsg 3 in cleavage associated with bullous skin disease
15) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.09 Pain Relevance 0
However, immunostaining of human epidermis using another monoclonal antibody detected expression of Dsg 3 in the lower epidermis only (Wu et al. 2000).
Gene_expression (expression) of Dsg 3 in epidermis
16) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.34 Pain Relevance 0
In oral mucosa, equally strong expression of Dsg 1 and Dsg 3 was found throughout the epithelium when specific antibodies were used (Mahoney et al. 2006), whereas Dsg 1 staining intensity was found to be much lower when PV-IgG were used for immunstaining (Shirakata et al. 1998).
Gene_expression (expression) of Dsg 3 in epithelium associated with bullous skin disease
17) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.35 Pain Relevance 0
Taken together, the expression patterns of Dsg 1 and Dsg 3 broadly overlap in human epidermis and appear to be identical in oral mucosa.
Gene_expression (expression) of Dsg 3 in epidermis
18) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.49 Pain Relevance 0
Dsg 1/Dsc 1 are the predominant desmosomal cadherins in the superficial epidermis, whereas Dsg 3/Dsc 3 are primarily expressed in the lower epidermis.
Gene_expression (expressed) of Dsg 3 in epidermis
19) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.07 Pain Relevance 0
In mice, expression of Dsg 3 is restricted to the basal and immediately suprabasal epidermal layer (Mahoney et al. 2006, 1999).
Gene_expression (expression) of Dsg 3
20) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.58 Pain Relevance 0

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