INT234858

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 4.58
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdh1) cell adhesion (Cdh1) Golgi apparatus (Cdh1)
plasma membrane (Cdh1) cytoplasm (Cdh1)
Anatomy Link Frequency
cleavage 1
epithelial cells 1
villus 1
HGF 1
keratinocyte 1
Cdh1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 26 90.92 High High
Crohn's disease 18 82.52 Quite High
COX2 2 47.24 Quite Low
cytokine 18 28.12 Quite Low
Kinase C 13 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 2 98.96 Very High Very High Very High
Sprains And Strains 138 98.52 Very High Very High Very High
Infection 293 96.72 Very High Very High Very High
Cancer 199 96.36 Very High Very High Very High
Bullous Skin Disease 304 96.24 Very High Very High Very High
Targeted Disruption 14 96.04 Very High Very High Very High
Disease 71 82.52 Quite High
Carcinoma 11 76.72 Quite High
Pathologic Processes 2 75.60 Quite High
Metastasis 53 71.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
E-cadherin forms homophilic cell-cell interactions and intracellularly binds to catenins (?
E-cadherin Binding (binds) of
1) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.44 Pain Relevance 0.06
To date E-cadherin has not been directly targeted in the mouse intestine to clarify its role in this tissue.
E-cadherin Binding (targeted) of in intestine
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.87 Pain Relevance 0.11
Finally, InlB promotes invasion of isolated intestinal epithelial cells when InlA-E-cadherin interactions are functional [20].
E-cadherin Binding (interactions) of in epithelial cells
3) Confidence 0.10 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.29 Pain Relevance 0
Interestingly, some internalized dextran at MCJs colocalizes with internalized E-cadherin as well as ZO-1, a scaffolding protein associated with the TJs in polarized cells (Figure 3E) [70].
E-cadherin Binding (associated) of
4) Confidence 0.10 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0 Pain Relevance 0
E-cadherin mainly binds to plasma membrane to mediate cell-cell interactions, when the membrane binding was destroyed through cleavage by ?
E-cadherin Binding (binds) of in cleavage
5) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912267 Disease Relevance 0.49 Pain Relevance 0
InlB has been shown to promote dynamin-dependent internalization of Listeria when the bacteria have access to the basolateral surface, and HGF similarly promotes internalization of E-cadherin when added to basal surfaces [59], [71].
E-cadherin Binding (internalization) of in HGF
6) Confidence 0.07 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0 Pain Relevance 0
Alternately, InlA was recently engineered to bind murine E-cadherin (InlAm) and is sufficient to reconstitute intestinal invasion after intragastric infection of mice [44], [45].
E-cadherin Binding (bind) of associated with infection
7) Confidence 0.07 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.89 Pain Relevance 0
We infected mice intragastrically with isogenic strains of Lm that express or lack InlB and that have a modified InlA capable of binding murine E-cadherin and found that Lm lacking InlB invade the same number of villi but have decreased numbers of bacteria within each infected villus tip.
E-cadherin Binding (binding) of in villus associated with sprains and strains
8) Confidence 0.07 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2869327 Disease Relevance 0.10 Pain Relevance 0.05
We chose to use an InlA mutation that is capable of binding murine E-cadherin (InlAm) [44].
E-cadherin Binding (binding) of
9) Confidence 0.07 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.06 Pain Relevance 0
Compared to isotype controls, USC-HN1 displays significantly increased staining of FABP5, E-cadherin, and CD24.
E-cadherin Binding (staining) of
10) Confidence 0.06 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.42 Pain Relevance 0
Other signatures of up-regulated genes in USC-HN1 cells include ATP5H, HSP27, FABP5, E-cadherin, EIF4G2, KRT18 and KRT8, RPLP0 and RPS18, which are associated with various biological processes such as cell growth and maintenance, cell cycle regulation, metabolism, and protein translation and synthesis (Table 4).


E-cadherin Binding (associated) of
11) Confidence 0.06 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.29 Pain Relevance 0
Pemphigus IgG were found to include a plethora of more than 20 different autoantibodies against keratinocyte antigens such as antibodies against Dsg 1, Dsg 4, Dsc 1-3, desmoplakin, plakoglobin and E-cadherin and several other proteins not associated with cell junctions (Amagai et al. 2006; Evangelista et al. 2008; Kljuic et al. 2003; Korman et al. 1989; Nguyen et al. 2000c).
E-cadherin Binding (associated) of in keratinocyte associated with bullous skin disease
12) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.74 Pain Relevance 0

General Comments

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