INT234862

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 3.29
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsc2) plasma membrane (Dsc2)
Anatomy Link Frequency
epidermis 3
plaque 1
internal 1
Dsc2 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 14 34.68 Quite Low
Kinase C 91 5.00 Very Low Very Low Very Low
metalloproteinase 42 5.00 Very Low Very Low Very Low
agonist 35 5.00 Very Low Very Low Very Low
corticosteroid 14 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 2245 99.24 Very High Very High Very High
Autoimmune Disease 43 98.84 Very High Very High Very High
Carcinoma 7 98.20 Very High Very High Very High
Skin Cancer 7 97.44 Very High Very High Very High
Breast Cancer 7 95.08 Very High Very High Very High
Disease 177 91.64 High High
Acantholysis 479 90.12 High High
Adhesions 399 87.68 High High
Cancer 21 80.24 Quite High
Salivary Gland Disease 7 69.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, in humans and cows, it is known that Dsc2 is only weakly expressed or even absent in most of the interfollicular epidermis, with the notable exception of the palms and soles (see [9]).
Neg (absent) Gene_expression (expressed) of Dsc2 in epidermis
1) Confidence 0.70 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.36 Pain Relevance 0
Data from bovine samples indicated that Dsc2 is strongly expressed throughout all layers of internal stratified epithelia, such as tongue [10–13].
Gene_expression (expressed) of Dsc2 in internal
2) Confidence 0.70 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.23 Pain Relevance 0
Nevertheless, in humans and cows, it is known that Dsc2 is only weakly expressed or even absent in most of the interfollicular epidermis, with the notable exception of the palms and soles (see [9]).
Neg (absent) Gene_expression (absent) of Dsc2 in epidermis
3) Confidence 0.55 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.36 Pain Relevance 0
Some desmosomal components such as Dsg 2, Dsc 2 and the plaque proteins desmoplakin, plakoglobin and plakophilin 2 are ubiquitously expressed in all cells and tissues in which desmosomes are found.
Gene_expression (expressed) of Dsc 2 in plaque
4) Confidence 0.22 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.09 Pain Relevance 0
Simple epithelia and urothelium usually express Dsg 2 and Dsc 2 only.
Gene_expression (express) of Dsc 2
5) Confidence 0.22 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.14 Pain Relevance 0
Although altered expression of desmosomal cadherins such as Dsg 2/Dsc 2 and Dsg 3/Dsc 3 have been observed in human carcinomas such as squamous cell carcinoma as well as gastric, colorectal and breast carcinomas, mutations are usually absent (Bazzi and Christiano 2007).
Gene_expression (expression) of Dsc 2 associated with breast cancer, carcinoma and skin cancer
6) Confidence 0.22 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.95 Pain Relevance 0
However, a recent comprehensive set of studies unequivocally demonstrated that the desmosomal components desmoglein 2 (Dsg 2), desmocollin 2 (Dsc 2), desmoplakin and plakophilin-2 as well as the adherens junction components N-cadherin, cadherin-11, ?
Gene_expression (components) of desmocollin 2
7) Confidence 0.19 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0 Pain Relevance 0
Dsc 2 is enriched in the deep epidermis with lower levels in the superficial epidermis, whereas Dsg 2 is restricted to basal and suprabasal cells but is present in very faint amounts only (Mahoney et al. 2006) indicating that this pair of proteins may be primarily important for cell cohesion in simple epithelia and myocardium rather than in complex epithelia.
Gene_expression (enriched) of Dsc 2 in epidermis
8) Confidence 0.19 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.05 Pain Relevance 0
Simple epithelia and urothelium usually express Dsg 2 and Dsc 2 only.
Gene_expression (express) of Dsc 2
9) Confidence 0.19 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.14 Pain Relevance 0
Although altered expression of desmosomal cadherins such as Dsg 2/Dsc 2 and Dsg 3/Dsc 3 have been observed in human carcinomas such as squamous cell carcinoma as well as gastric, colorectal and breast carcinomas, mutations are usually absent (Bazzi and Christiano 2007).
Gene_expression (expression) of Dsc 2 associated with breast cancer, carcinoma and skin cancer
10) Confidence 0.19 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.95 Pain Relevance 0

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