INT234864

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 17.72
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dsp) structural molecule activity (Dsp) cytoskeleton (Dsp)
protein binding, bridging (Dsp) cytoplasm (Dsp)
Anatomy Link Frequency
keratinocyte 3
plaque 2
skin 2
CAR 1
cardiomyocytes 1
Dsp (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 24 99.78 Very High Very High Very High
Dopamine 7 78.24 Quite High
Neurotransmitter 1 73.32 Quite High
imagery 32 61.80 Quite High
Eae 18 58.80 Quite High
Kinase C 377 56.32 Quite High
bDMF 1 50.64 Quite High
addiction 58 49.68 Quite Low
monoamine 2 47.72 Quite Low
amygdala 2 34.36 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 1479 100.00 Very High Very High Very High
Disease 523 99.80 Very High Very High Very High
Bullous Skin Disease 8816 99.48 Very High Very High Very High
Autoimmune Disease 116 98.84 Very High Very High Very High
Skin Infection 116 98.60 Very High Very High Very High
Acantholysis 1885 98.40 Very High Very High Very High
Carcinoma 29 97.00 Very High Very High Very High
Skin Cancer 29 96.24 Very High Very High Very High
Skin Diseases 145 94.40 High High
Breast Cancer 29 93.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A database search using Allen Brain Atlas [23] revealed that, among the 20 most downregulated genes in the alpha-CaMKII +/- hippocampus, 5 genes (DSP, TDO2, NPNT, IL1R1, and PNCK) had highly selective expression in the DG (Figure 2E–2J, and Additional file 1, Figure S6).
Gene_expression (expression) of DSP in Atlas associated with hippocampus
1) Confidence 0.47 Published 2008 Journal Mol Brain Section Body Doc Link PMC2562999 Disease Relevance 0.09 Pain Relevance 0.31
Although altered expression of desmosomal cadherins such as Dsg 2/Dsc 2 and Dsg 3/Dsc 3 have been observed in human carcinomas such as squamous cell carcinoma as well as gastric, colorectal and breast carcinomas, mutations are usually absent (Bazzi and Christiano 2007).
Gene_expression (expression) of desmosomal associated with breast cancer, carcinoma and skin cancer
2) Confidence 0.04 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.95 Pain Relevance 0
Fig. 4Expression patterns of desmosomal components in the epidermis.
Gene_expression (4Expression) of desmosomal in epidermis
3) Confidence 0.04 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.09 Pain Relevance 0
Some desmosomal components such as Dsg 2, Dsc 2 and the plaque proteins desmoplakin, plakoglobin and plakophilin 2 are ubiquitously expressed in all cells and tissues in which desmosomes are found.
Gene_expression (expressed) of desmosomal in plaque
4) Confidence 0.04 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.09 Pain Relevance 0
On the right, the expression patterns of desmosomal components in the specific epidermal layers are illustrated.
Gene_expression (expression) of desmosomal
5) Confidence 0.04 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.08 Pain Relevance 0
The electron micrograph of a keratinocyte desmosome shows the desmosomal plaque with inserting cytokeratin intermediate filaments as well as some fuzzy material within the extracellular space likely reflecting the extracellular domains of desmosomal cadherins

Desmosomes and desmosome-like junctions

Gene_expression (cadherins) of desmosomal in keratinocyte
6) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.08 Pain Relevance 0
Desmosomal cadherins
Gene_expression (cadherins) of Desmosomal
7) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.22 Pain Relevance 0
Several diseases have been found in which impaired desmosomal adhesion contributes to pathogenesis.
Gene_expression (adhesion) of desmosomal associated with disease and adhesions
8) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.70 Pain Relevance 0
Recently, in meningeoma cells, a new type of adhering junctions was discovered in which adherens junctions also contained the desmosomal plaque protein plakophilin 2 (Akat et al. 2008).


Gene_expression (contained) of desmosomal in plaque
9) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.15 Pain Relevance 0
This article focuses on the mechanisms regulating desmosomal adhesion, which are compromised in diseases such as pemphigus.


Gene_expression (adhesion) of desmosomal associated with bullous skin disease, disease and adhesions
10) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.67 Pain Relevance 0
These may involve different signalling pathways required for maintenance of desmosomal adhesion in the specific epidermal layers as outlined below.


Gene_expression (adhesion) of desmosomal associated with adhesions
11) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.03 Pain Relevance 0
Homophilic and heterophilic binding of desmosomal cadherins
Gene_expression (Homophilic) of desmosomal
12) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0 Pain Relevance 0.03
Moreover, future experiments may reveal how the different signalling pathways are involved in the regulation of desmosomal adhesion in the specific epidermal layers.
Gene_expression (adhesion) of desmosomal associated with adhesions
13) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.07 Pain Relevance 0.03
On the other hand, because plakophilin 1 is located in the dense inner desmosomal plaque whereas cytokeratin filaments only loop into the outer plaque, it is believed that plakophilin 1 enhances desmoplakin lateral interactions but does not directly associate with cytokeratin filaments in vivo (Hatzfeld 2007; North et al. 1999).
Gene_expression (plaque) of desmosomal in lateral
14) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.11 Pain Relevance 0
This view seemed to be supported by immuno-localization studies, which showed that desmoplakin as a desmosomal marker and the myocardial adherens junction protein N-cadherin displayed mutually exclusive spatial distribution patterns (Angst et al. 1997; Gutstein et al. 2003).
Gene_expression (marker) of desmosomal
15) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0 Pain Relevance 0
Disturbed desmosomal adhesion contributes to the pathogenesis of a number of diseases such as pemphigus, which is caused by autoantibodies against desmosomal cadherins.
Gene_expression (adhesion) of desmosomal associated with bullous skin disease, disease and adhesions
16) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Abstract Doc Link PMC2413110 Disease Relevance 1.08 Pain Relevance 0
However, a recent comprehensive set of studies unequivocally demonstrated that the desmosomal components desmoglein 2 (Dsg 2), desmocollin 2 (Dsc 2), desmoplakin and plakophilin-2 as well as the adherens junction components N-cadherin, cadherin-11, ?
Gene_expression (components) of desmosomal
17) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0 Pain Relevance 0
With respect to pemphigus, it has been shown that plakoglobin is critical for PV pathogenesis because keratinocytes from plakoglobin-deficient mice were resistant to PV-IgG-induced keratinocyte dissociation, cytokeratin retraction and disruption of the desmosomal plaque (Caldelari et al. 2001; de Bruin et al. 2007).
Gene_expression (retraction) of desmosomal in keratinocytes associated with bullous skin disease
18) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.74 Pain Relevance 0
The desmosomal components
Gene_expression (components) of desmosomal
19) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.21 Pain Relevance 0
Therefore, autoantibodies from pemphigus patients have been used to characterize the mechanisms involved in the regulation of desmosomal adhesion.
Gene_expression (adhesion) of desmosomal associated with bullous skin disease and adhesions
20) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.46 Pain Relevance 0

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