INT234865

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 2.48
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dsp) structural molecule activity (Dsp) cytoskeleton (Dsp)
protein binding, bridging (Dsp) cytoplasm (Dsp)
Anatomy Link Frequency
filaments 1
skin 1
keratinocyte 1
Dsp (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 10 98.08 Very High Very High Very High
Kinase C 130 92.92 High High
addiction 20 49.12 Quite Low
metalloproteinase 60 5.00 Very Low Very Low Very Low
agonist 50 5.00 Very Low Very Low Very Low
corticosteroid 20 5.00 Very Low Very Low Very Low
Inflammatory mediators 10 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acantholysis 650 97.74 Very High Very High Very High
Adhesions 510 95.32 Very High Very High Very High
Stress 40 89.68 High High
Bullous Skin Disease 3040 85.68 High High
Non-genital Cutaneous Warts 10 77.88 Quite High
Heart Defects 40 69.24 Quite High
Death 10 68.40 Quite High
Disease 180 54.52 Quite High
Hepatitis A Virus Infection 10 47.20 Quite Low
Salivary Gland Disease 10 30.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to these functional studies, morphologic studies sought to address the mode of desmosomal cadherin interaction within desmosomes by using electron tomography imaging of epidermal tissue (Al-Amoudi et al. 2007; He et al. 2003).
desmosomal cadherin Binding (interaction) of associated with imagery
1) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.41 Pain Relevance 0.05
For instance, acantholysis may foster skin blistering by derangement of the epidermal Ca2+ gradient, which in turn would result in loss of desmosomal cadherin binding, especially when the tight junctions of the granular layer are affected.



desmosomal cadherin Binding (binding) of in skin associated with acantholysis
2) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.49 Pain Relevance 0.04
The electron micrograph of a keratinocyte desmosome shows the desmosomal plaque with inserting cytokeratin intermediate filaments as well as some fuzzy material within the extracellular space likely reflecting the extracellular domains of desmosomal cadherins

Desmosomes and desmosome-like junctions

desmosomal Spec (like) Binding (shows) of in keratinocyte
3) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.06 Pain Relevance 0
Desmosomal plaques with inserted cytokeratin filaments became visible as early as after 5 min after the Ca2+ switch followed by appearance of assymetrical desmosomes after 10 min and of symmetric desmosomes after 1 h.
Desmosomal Binding (plaques) of in filaments
4) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.13 Pain Relevance 0.13
The desmosomal cadherins desmoglein and desmocollin undergo homophilic and heterophilic binding via interaction with the amino-terminal extracellular (EC) 1 domain of partner molecules on the same (cis) as well as on the neighbouring cell (trans).
desmosomal Binding (binding) of
5) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.16 Pain Relevance 0
However, it is unclear at present which desmosomal cadherin isoforms are capable to heretophilically bind to each other and thus interpretation of these distribution patterns with respect to their relevance for mechanical adhesion is preliminary.
desmosomal cadherin Binding (bind) of associated with adhesions
6) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.10 Pain Relevance 0
Plakophilin 1 recruits desmosomal components to the cell membrane, increases size and number of desmosomes and therefore seems to be a scaffolding protein, which induces desmosome assembly (Hatzfeld et al. 2000; Kowalczyk et al. 1999; Wahl 2005).
desmosomal Binding (components) of
7) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.14 Pain Relevance 0
The Ca2+-dependency of desmosomal cadherin-mediated binding
desmosomal cadherin Binding (binding) of
8) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0 Pain Relevance 0
It is well established that binding of desmosomal and classical cadherins is strictly Ca2+-dependent (Chitaev and Troyanovsky 1997; Heupel et al. 2007; Pertz et al. 1999; Waschke et al. 2007).
desmosomal Binding (binding) of
9) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0 Pain Relevance 0
Homophilic and heterophilic binding of desmosomal cadherins
desmosomal Binding (binding) of
10) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0 Pain Relevance 0.03

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