INT234866

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.58
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Jup) cytoplasm (Jup) cytosol (Jup)
structural molecule activity (Jup) cell adhesion (Jup) nucleus (Jup)
Jup (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 60 66.20 Quite High
Kinase C 13 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 28 91.52 High High
Adhesions 51 77.84 Quite High
Acantholysis 65 76.28 Quite High
Bullous Skin Disease 304 70.60 Quite High
Congenital Anomalies 14 56.68 Quite High
Arrhythmogenic Right Ventricular Dysplasia 11 50.00 Quite Low
Cleidocranial Dysplasia 8 50.00 Quite Low
Apoptosis 19 5.00 Very Low Very Low Very Low
Blister 12 5.00 Very Low Very Low Very Low
Fibrosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The linker function of plakoglobin seems to be regulated by tyrosine phosphorylation of plakoglobin because following EGFR activation, phosphorylated plakoglobin remained associated with Dsg 2 but not with desmoplakin (Gaudry et al. 2001).
Regulation (regulated) of plakoglobin
1) Confidence 0.08 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.35 Pain Relevance 0
They showed an excellent diagnostic value of reduced plakoglobin levels in the biopsy sample, with a sensitivity of 91%, a specificity of 82%, a positive predictive value of 83%, and a negative predictive value of 90%.
Regulation (value) of plakoglobin
2) Confidence 0.01 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933459 Disease Relevance 0.23 Pain Relevance 0.06

General Comments

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