INT234867

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.84
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Jup) cytoplasm (Jup) cytosol (Jup)
structural molecule activity (Jup) cell adhesion (Jup) nucleus (Jup)
Anatomy Link Frequency
cardiomyocytes 1
nucleus 1
Jup (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 6 58.72 Quite High
Kinase C 39 5.00 Very Low Very Low Very Low
metalloproteinase 18 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Defects 12 99.56 Very High Very High Very High
Arrhythmogenic Right Ventricular Dysplasia 9 99.16 Very High Very High Very High
Adhesions 153 96.32 Very High Very High Very High
Alopecia 6 95.24 Very High Very High Very High
Arrhythmia Under Development 3 94.56 High High
Disease 54 88.80 High High
Skin Diseases 15 87.84 High High
Vohwinkel Syndrome 18 86.16 High High
Cv General 4 Under Development 3 83.60 Quite High
Embryonic Lethality 9 82.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In consequence, GSK3 phosphorylation-dependent degradation of plakoglobin is abolished which allows plakoglobin to translocate into the nucleus and to induce growth arrest via suppression of c-Myc (Muller et al. 2008a; Williamson et al. 2006).


Localization (translocate) of plakoglobin in nucleus
1) Confidence 0.24 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.45 Pain Relevance 0.03
-catenin signalling in response to nuclear translocation of plakoglobin (Garcia-Gras et al. 2006).


Localization (translocation) of plakoglobin
2) Confidence 0.24 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.09 Pain Relevance 0
Interestingly, all defects of desmosomal components causing heart defects such as desmoplakin, plakoglobin, plakophilin 2, Dsg 2 and Dsc 2 lead to the phenotype of arrhythmogenic right ventricular cardiomyopathy (ARVC) which is clinically characterized by right bundle block and arrhythmia and histologically by fibrofatty replacement of cardiomyocytes, possibly due to impaired cell adhesion caused by loss and alterations of desmosomes (Asimaki et al. 2007; Gerull et al. 2004; McKoy et al. 2000; Pilichou et al. 2006; Rampazzo et al. 2002; Syrris et al. 2006; Heuser et al. 2006).
Localization (lead) of plakoglobin in cardiomyocytes associated with arrhythmia under development, heart defects, adhesions and arrhythmogenic right ventricular dysplasia
3) Confidence 0.22 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.30 Pain Relevance 0

General Comments

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