INT234869

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 5.34
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg2) plasma membrane (Dsg2)
Anatomy Link Frequency
other parts 2
Dsg2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 36 75.40 Quite High
Kinase C 78 72.08 Quite High
Inflammatory mediators 6 37.32 Quite Low
agonist 30 5.00 Very Low Very Low Very Low
corticosteroid 12 5.00 Very Low Very Low Very Low
addiction 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 1824 99.74 Very High Very High Very High
Adhesions 306 98.60 Very High Very High Very High
Acantholysis 390 95.12 Very High Very High Very High
Streptococcus Infection 12 91.48 High High
Stress 24 79.20 Quite High
Apoptosis 114 51.88 Quite High
Blister 72 44.84 Quite Low
Autoimmune Disease 24 42.60 Quite Low
INFLAMMATION 6 36.92 Quite Low
Disease 108 21.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The major goal for the future is to elucidate the primary signalling pathways responsible for the diverse effects of pemphigus IgG such as inhibition of desmoglein binding, depletion of desmosomal components, loss of desmosomes, reorganization of the cytoskeleton and finally the induction of acantholysis.
Negative_regulation (inhibition) of desmoglein Binding (binding) of associated with acantholysis and bullous skin disease
1) Confidence 0.12 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.37 Pain Relevance 0.04
Later on, with the identification of desmosomal cadherins as the target antigens of pemphigus autoantibodies and with more sophisticated cell biologic tools at hand, the ideas of direct antibody-mediated inhibition and of indirect signalling-mediated reduction of desmoglein binding were developed (Fig. 8).
Negative_regulation (reduction) of desmoglein Binding (binding) of associated with bullous skin disease
2) Confidence 0.12 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.01 Pain Relevance 0
An antibody directed against the putative transadhesive interface may directly induce steric hindrance, whereas antibodies directed against other parts of the desmoglein ectodomain could indirectly inhibit desmoglein binding by allosteric mechanisms.
Negative_regulation (inhibit) of desmoglein Binding (binding) of in other parts
3) Confidence 0.12 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.26 Pain Relevance 0
Since it was discovered that autoantibodies in pemphigus are directed to desmosomal adhesion molecules, it was believed that these autoantibodies might directly interfere with desmoglein binding (Fig. 8) (Amagai et al. 1991; Jones et al. 1986a; Koulu et al. 1984), a mechanism also refered to as “steric hindrance”(Sharma et al. 2007).
Spec (might) Negative_regulation (interfere) of desmoglein Spec (might) Binding (binding) of associated with bullous skin disease and adhesions
4) Confidence 0.09 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.15 Pain Relevance 0.03
Therefore, “direct inhibition”, instead of “steric hindrance” of desmoglein binding should be used until discrimination between steric and allosteric effects is possible.


Negative_regulation (hindrance) of desmoglein Binding (binding) of
5) Confidence 0.09 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.31 Pain Relevance 0
Direct inhibition of desmoglein binding
Negative_regulation (inhibition) of desmoglein Binding (binding) of
6) Confidence 0.09 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.25 Pain Relevance 0.04

General Comments

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