INT234880

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.75
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dsp) structural molecule activity (Dsp) cytoskeleton (Dsp)
protein binding, bridging (Dsp) cytoplasm (Dsp)
Dsp (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 65 56.88 Quite High
addiction 10 35.00 Quite Low
metalloproteinase 30 5.00 Very Low Very Low Very Low
agonist 25 5.00 Very Low Very Low Very Low
corticosteroid 10 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 255 100.00 Very High Very High Very High
Bullous Skin Disease 1520 99.56 Very High Very High Very High
Autoimmune Disease 20 99.16 Very High Very High Very High
Disease 90 98.92 Very High Very High Very High
Carcinoma 5 97.00 Very High Very High Very High
Skin Cancer 5 96.24 Very High Very High Very High
Breast Cancer 5 93.88 High High
Acantholysis 325 91.44 High High
Cancer 15 77.84 Quite High
Blister 60 72.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data are in contrast to previous findings, which suggested that Rho GTPases are not involved in the regulation of desmosomal adhesion.
Regulation (regulation) of Gene_expression (adhesion) of desmosomal associated with adhesions
1) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.54 Pain Relevance 0
Therefore, autoantibodies from pemphigus patients have been used to characterize the mechanisms involved in the regulation of desmosomal adhesion.
Regulation (regulation) of Gene_expression (adhesion) of desmosomal associated with bullous skin disease and adhesions
2) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.47 Pain Relevance 0
This article focuses on the mechanisms regulating desmosomal adhesion, which are compromised in diseases such as pemphigus.


Regulation (regulating) of Gene_expression (adhesion) of desmosomal associated with bullous skin disease, disease and adhesions
3) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.68 Pain Relevance 0
Moreover, future experiments may reveal how the different signalling pathways are involved in the regulation of desmosomal adhesion in the specific epidermal layers.
Regulation (regulation) of Gene_expression (adhesion) of desmosomal associated with adhesions
4) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.12 Pain Relevance 0.03
Although altered expression of desmosomal cadherins such as Dsg 2/Dsc 2 and Dsg 3/Dsc 3 have been observed in human carcinomas such as squamous cell carcinoma as well as gastric, colorectal and breast carcinomas, mutations are usually absent (Bazzi and Christiano 2007).
Regulation (altered) of Gene_expression (expression) of desmosomal associated with breast cancer, carcinoma and skin cancer
5) Confidence 0.01 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.95 Pain Relevance 0

General Comments

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