INT234887

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.80
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg3) plasma membrane (Dsg3)
Anatomy Link Frequency
epidermis 2
Dsg3 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 2 86.24 High High
addiction 4 68.68 Quite High
Kinase C 26 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 608 95.20 Very High Very High Very High
Disease 36 73.76 Quite High
Adhesions 102 69.44 Quite High
Hepatitis A Virus Infection 2 51.92 Quite High
Autoimmune Disease 8 42.72 Quite Low
Carcinoma 2 31.04 Quite Low
Skin Cancer 2 29.52 Quite Low
Breast Cancer 2 24.80 Low Low
Darier's Disease 2 16.52 Low Low
Cancer 6 14.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together with the recent finding that AK 23 similar to Dsg 3 antibodies from PV patients, which are known to be also primarily directed against the N-terminal part of EC 1 (Sekiguchi et al. 2001), is able to directly interfere with Dsg 3 binding (Heupel et al. 2007), these data demonstrate that interaction of EC 1 is crucial for Dsg 3 binding.
Positive_regulation (crucial) of Dsg 3 Binding (binding) of associated with bullous skin disease
1) Confidence 0.26 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.49 Pain Relevance 0.04
According to this concept, in healthy epidermis Dsg 3 binding results in inhibition of glycogen synthase kinase 3 (GSK3) via activation of phosphatidylinositol trisphosphate kinase (PI3K) and Akt.
Positive_regulation (activation) of Dsg 3 Binding (binding) of in epidermis
2) Confidence 0.23 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.30 Pain Relevance 0.03

General Comments

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