INT234890

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.56
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Jup) cytoplasm (Jup) cytosol (Jup)
structural molecule activity (Jup) cell adhesion (Jup) nucleus (Jup)
Anatomy Link Frequency
nucleus 1
Jup (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 8 61.88 Quite High
Kinase C 52 5.00 Very Low Very Low Very Low
metalloproteinase 24 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 204 97.76 Very High Very High Very High
Disease 72 84.56 Quite High
Bullous Skin Disease 1216 83.52 Quite High
Acantholysis 260 74.44 Quite High
Autoimmune Disease 16 53.52 Quite High
Carcinoma 4 41.84 Quite Low
Skin Cancer 4 40.32 Quite Low
Breast Cancer 4 35.60 Quite Low
Cancer 12 25.68 Quite Low
Darier's Disease 4 9.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, plakoglobin phosphorylation was shown to be required for EGFR-induced loss of cell adhesion and to regulate binding of plakoglobin to desmoplakin (Miravet et al. 2003; Yin et al. 2005).
Phosphorylation (phosphorylation) of plakoglobin associated with adhesions
1) Confidence 0.24 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.42 Pain Relevance 0
The linker function of plakoglobin seems to be regulated by tyrosine phosphorylation of plakoglobin because following EGFR activation, phosphorylated plakoglobin remained associated with Dsg 2 but not with desmoplakin (Gaudry et al. 2001).
Phosphorylation (phosphorylation) of plakoglobin
2) Confidence 0.24 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.35 Pain Relevance 0
The linker function of plakoglobin seems to be regulated by tyrosine phosphorylation of plakoglobin because following EGFR activation, phosphorylated plakoglobin remained associated with Dsg 2 but not with desmoplakin (Gaudry et al. 2001).
Phosphorylation (phosphorylated) of plakoglobin
3) Confidence 0.24 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.36 Pain Relevance 0
In consequence, GSK3 phosphorylation-dependent degradation of plakoglobin is abolished which allows plakoglobin to translocate into the nucleus and to induce growth arrest via suppression of c-Myc (Muller et al. 2008a; Williamson et al. 2006).


Phosphorylation (phosphorylation) of plakoglobin in nucleus
4) Confidence 0.19 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.44 Pain Relevance 0.03

General Comments

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