INT234892

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plaque 2
heart 1
Pkp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 52 5.00 Very Low Very Low Very Low
metalloproteinase 24 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
addiction 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 72 89.28 High High
Heart Defects 16 82.96 Quite High
Death 4 82.12 Quite High
Adhesions 204 81.52 Quite High
Cancer 12 40.36 Quite Low
Salivary Gland Disease 4 39.84 Quite Low
Apoptosis 76 29.84 Quite Low
Repression 8 18.80 Low Low
Bullous Skin Disease 1216 5.00 Very Low Very Low Very Low
Acantholysis 260 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some desmosomal components such as Dsg 2, Dsc 2 and the plaque proteins desmoplakin, plakoglobin and plakophilin 2 are ubiquitously expressed in all cells and tissues in which desmosomes are found.
Gene_expression (expressed) of plakophilin 2 in plaque
1) Confidence 0.06 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.09 Pain Relevance 0
Because cardiomyocytes in contrast to epithelial cells express only plakophilin 2 but not plakophilin 1 and 3, defects were present in the heart only, whereas epithelia were not affected.
Gene_expression (express) of plakophilin 2 in heart
2) Confidence 0.06 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.17 Pain Relevance 0
Recently, in meningeoma cells, a new type of adhering junctions was discovered in which adherens junctions also contained the desmosomal plaque protein plakophilin 2 (Akat et al. 2008).


Gene_expression (contained) of plakophilin 2 in plaque
3) Confidence 0.05 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.15 Pain Relevance 0
However, a recent comprehensive set of studies unequivocally demonstrated that the desmosomal components desmoglein 2 (Dsg 2), desmocollin 2 (Dsc 2), desmoplakin and plakophilin-2 as well as the adherens junction components N-cadherin, cadherin-11, ?
Gene_expression (components) of plakophilin-2
4) Confidence 0.05 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0 Pain Relevance 0

General Comments

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