INT234893

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.78
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adam17) extracellular region (Adam17) cell motility (Adam17)
cell adhesion (Adam17) plasma membrane (Adam17) cytoplasm (Adam17)
Anatomy Link Frequency
leukocytes 1
Adam17 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 51 99.78 Very High Very High Very High
Inflammation 93 96.24 Very High Very High Very High
cytokine 18 88.96 High High
rheumatoid arthritis 1 86.80 High High
Inflammatory mediators 4 84.32 Quite High
cINOD 45 68.80 Quite High
ischemia 1 62.04 Quite High
fibrosis 40 50.00 Quite Low
Kinase C 13 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 5 99.68 Very High Very High Very High
Autoimmune Disease 23 99.24 Very High Very High Very High
Apoptosis 36 98.88 Very High Very High Very High
Systemic Sclerosis 2 97.76 Very High Very High Very High
Systemic Lupus Erythematosus 2 96.68 Very High Very High Very High
Bullous Skin Disease 305 96.28 Very High Very High Very High
INFLAMMATION 105 96.24 Very High Very High Very High
Hepatitis 12 95.52 Very High Very High Very High
Injury 55 94.16 High High
Liver Disease 9 91.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since TACE is one of the major activators of TNF-?
Positive_regulation (activators) of TACE
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.74 Pain Relevance 0.15
has been reported to increase ADAM-17 and ADAM-10 levels and ?
Positive_regulation (increase) of ADAM-17
2) Confidence 0.30 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.47 Pain Relevance 0.27
ADAM17 on the other hand, was upregulated by activation of the epidermal growth factor receptor (EGFR) and caused shedding of Dsg 2 (Bech-Serra et al. 2006; Santiago-Josefat et al. 2007).
Positive_regulation (upregulated) of ADAM17
3) Confidence 0.24 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.20 Pain Relevance 0.25
In terms of autoimmune disease several metalloproteinases including ADAM-17, MMP-9, MMP-3, MMP-2, or MMP-8 are reportedly increased in the serum or peripheral leukocytes of patients with systemic sclerosis, system lupus erythematosus, and Wegener's granulomatosis [106–109].
Positive_regulation (increased) of ADAM-17 in leukocytes associated with autoimmune disease, metalloproteinase, systemic lupus erythematosus and systemic sclerosis
4) Confidence 0.14 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.37 Pain Relevance 0.56

General Comments

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