INT234899

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.88
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Jup) cytoplasm (Jup) cytosol (Jup)
structural molecule activity (Jup) cell adhesion (Jup) nucleus (Jup)
Anatomy Link Frequency
nucleus 4
Jup (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 4 61.24 Quite High
Kinase C 26 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 36 86.64 High High
Bullous Skin Disease 608 82.88 Quite High
Adhesions 102 80.96 Quite High
Autoimmune Disease 8 55.60 Quite High
Carcinoma 2 43.92 Quite Low
Skin Cancer 2 42.40 Quite Low
Breast Cancer 2 37.68 Quite Low
Cancer 6 27.76 Quite Low
Darier's Disease 2 9.08 Low Low
Acantholysis 130 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In consequence, GSK3 phosphorylation-dependent degradation of plakoglobin is abolished which allows plakoglobin to translocate into the nucleus and to induce growth arrest via suppression of c-Myc (Muller et al. 2008a; Williamson et al. 2006).


Positive_regulation (dependent) of Protein_catabolism (degradation) of plakoglobin in nucleus
1) Confidence 0.21 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.44 Pain Relevance 0.03
In consequence, GSK3 phosphorylation-dependent degradation of plakoglobin is abolished which allows plakoglobin to translocate into the nucleus and to induce growth arrest via suppression of c-Myc (Muller et al. 2008a; Williamson et al. 2006).


Positive_regulation (allows) of Protein_catabolism (degradation) of plakoglobin in nucleus
2) Confidence 0.14 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.45 Pain Relevance 0.03

General Comments

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