INT234901

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.94
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg3) plasma membrane (Dsg3)
Anatomy Link Frequency
epidermis 6
Dsg3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 52 46.96 Quite Low
metalloproteinase 24 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
addiction 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 1216 97.80 Very High Very High Very High
Acantholysis 260 97.12 Very High Very High Very High
Non-genital Cutaneous Warts 4 76.16 Quite High
Blister 48 70.12 Quite High
Adhesions 204 38.08 Quite Low
Disease 72 34.52 Quite Low
Apoptosis 76 31.28 Quite Low
Vohwinkel Syndrome 24 5.00 Very Low Very Low Very Low
Skin Diseases 20 5.00 Very Low Very Low Very Low
Heart Defects 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In line with these findings, forced expression of Dsg 3 in the superficial epidermis abolished the ability of PF-IgG to induce acantholysis in mice (Wu et al. 2000).
Positive_regulation (forced) of Gene_expression (expression) of Dsg 3 in epidermis associated with acantholysis and bullous skin disease
1) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.88 Pain Relevance 0
It was shown that forced overexpression of Dsg 3 in the suprabasal epidermis led to abnormal differentiation and hyperproliferation as well as perinatal lethality due to transepidermal water loss (Elias et al. 2001; Merritt et al. 2002).
Positive_regulation (overexpression) of Gene_expression (overexpression) of Dsg 3 in epidermis
2) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.08 Pain Relevance 0
This effect was mediated by Dsg 3-specific antibodies because monoclonal Dsg 3 antibodies such as AK23 were effective to induce Dsg 3 depletion and this effect correlated with the pathogenic activity of these autoantibodies in vivo and in vitro (Shu et al. 2007; Yamamoto et al. 2007a).
Positive_regulation (induce) of Gene_expression (depletion) of Dsg 3
3) Confidence 0.26 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.21 Pain Relevance 0
In skin layers where Dsg 1 and Dsg 3 were found, autoantibodies against both desmogleins were required for blistering.
Positive_regulation (required) of Gene_expression (found) of Dsg 3 in skin
4) Confidence 0.26 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.78 Pain Relevance 0

General Comments

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