INT234903

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 7.10
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Jup) cytoplasm (Jup) cytosol (Jup)
structural molecule activity (Jup) cell adhesion (Jup) nucleus (Jup)
Anatomy Link Frequency
keratinocytes 3
plaque 2
epithelial cells 1
skin 1
Jup (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 143 80.88 Quite High
agonist 55 66.28 Quite High
antagonist 11 44.04 Quite Low
metalloproteinase 66 5.00 Very Low Very Low Very Low
corticosteroid 22 5.00 Very Low Very Low Very Low
addiction 22 5.00 Very Low Very Low Very Low
Inflammatory mediators 11 5.00 Very Low Very Low Very Low
Pain 11 5.00 Very Low Very Low Very Low
imagery 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 209 100.00 Very High Very High Very High
Repression 22 100.00 Very High Very High Very High
Bullous Skin Disease 3344 99.74 Very High Very High Very High
Cancer 33 99.40 Very High Very High Very High
Acantholysis 715 98.56 Very High Very High Very High
Adhesions 561 94.56 High High
Disease 198 89.92 High High
Embryonic Lethality 33 85.80 High High
Salivary Gland Disease 11 81.32 Quite High
Stress 44 66.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the epidermis, the plaque proteins plakoglobin, desmoplakin and plakophilin 3 are expressed in all layers (Fig. 4).
Gene_expression (expressed) of plakoglobin in plaque
1) Confidence 0.23 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.08 Pain Relevance 0
Some desmosomal components such as Dsg 2, Dsc 2 and the plaque proteins desmoplakin, plakoglobin and plakophilin 2 are ubiquitously expressed in all cells and tissues in which desmosomes are found.
Gene_expression (expressed) of plakoglobin in plaque
2) Confidence 0.23 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.09 Pain Relevance 0
In keratinoytes, c-Myc repression by plakoglobin is required to stop proliferation and to allow terminal differentiation (Williamson et al. 2006).
Gene_expression (repression) of plakoglobin associated with repression
3) Confidence 0.20 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.46 Pain Relevance 0
This can be concluded from experiments which showed that autoantibody binding as well as keratinocyte separation started between desmosomes (Sato et al. 2000; Takahashi et al. 1985) and that non-junctional Dsg 3 and plakoglobin were depleted first before changes in the desmosomal fractions were present (Aoyama and Kitajima 1999; Williamson et al. 2006; Yamamoto et al. 2007a).
Gene_expression (depleted) of plakoglobin in keratinocyte
4) Confidence 0.20 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.69 Pain Relevance 0.03
Moreover, altered plakoglobin signalling leading to c-Myc overexpression was found in PV patients’s skin but not in PF (Williamson et al. 2007, 2006).
Gene_expression (signalling) of plakoglobin in skin associated with bullous skin disease
5) Confidence 0.20 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 2.21 Pain Relevance 0.11
A target gene of Lef-1/plakoglobin signalling is c-Myc, the expression of which was inhibited in keratinocytes but enhanced in transformed rat kidney epithelial cells (Kolligs et al. 2000; Kolly et al. 2007; Williamson et al. 2006).
Gene_expression (signalling) of plakoglobin in epithelial cells
6) Confidence 0.20 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.25 Pain Relevance 0
Because plakoglobin like ?
Spec (like) Gene_expression (like) of plakoglobin
7) Confidence 0.20 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.13 Pain Relevance 0
These mechanisms may, amongst others, involve expression of genes different from c-Myc, which is suggested by the fact that plakoglobin deficiency resulted in protection of keratinocytes from apoptosis, possibly via overexpression of the anti-apoptotic molecule Bcl-XL (Dusek et al. 2007a).
Gene_expression (overexpression) of plakoglobin in keratinocytes associated with apoptosis
8) Confidence 0.20 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.49 Pain Relevance 0
As outlined above, PV-IgG-induced plakoglobin depletion resulted in c-Myc overexpression in cultured keratinocytes (Muller et al. 2008a; Williamson et al. 2006).
Gene_expression (depletion) of plakoglobin in keratinocytes associated with bullous skin disease
9) Confidence 0.20 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.09 Pain Relevance 0.06
It has been shown that plakoglobin, comparable to ?
Gene_expression (comparable) of plakoglobin
10) Confidence 0.20 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.09 Pain Relevance 0
This might also be important for cancer progression because many tumors are characterized by loss of plakoglobin expression.


Gene_expression (expression) of plakoglobin associated with cancer
11) Confidence 0.18 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.54 Pain Relevance 0

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